BioMimetirc Conditioning of Human Dentin Using Citric Acid

5 (2 votes)

CE Hours: 1.0 CE hour 

In carious teeth, transforming growth factor beta 1 (TGF-β1) is released from the dentin matrix and possibly activated in an acidic environment. Conversely, EDTA solutions with a neutral to slightly alkaline pH are used in clinics to promote cell homing in regenerative endodontic procedures. We hypothesized that citric acid (CA) might be more beneficial.

At the conclusion, participants should be able to:

  • Describe the concept of cell homing in the context of Regenerative Endodontics;
  • Discuss the key role of TGF-β1 in this concept;
  • Evaluate the role of pH in root dentin conditioning for regenerative procedures.


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Open to download resource.
7 Questions
CE Test
5 Questions  |  Unlimited attempts  |  4/5 points to pass
5 Questions  |  Unlimited attempts  |  4/5 points to pass
1.00 CE credit  |  Certificate available
1.00 CE credit  |  Certificate available

Anja Ivica, DDS

Matthias Zehnder, DDS, PhD

José M. Mateos, PhD

Chafik Ghayor, PhD

Franz E. Weber, PhD

We thank Andres Kaech for scientific comments; Gery Barmettler for technical support with sample preparation of the immunofluorescence experiments; Claudia Cucuzza and Beatrice Sener for swift laboratory work; and Tse-Hsiang Chen, Nupur Khera, Indranil Bhattacharya, Kathrin Schumann, and Ana Perez for their helpful advice.

Supported by a Swiss Government Excellence Scholarship (A.I.)

The authors deny any conflicts of interested related to this study