Nonsteroidal Anti-inflammatory Drugs for Managing Postoperative Endodontic Pain in Patients Who Present with Preoperative Pain: A Systematic Review and Meta-analysis

4 (4 votes)

Nonsteroidal anti-inflammatory drugs (NSAIDs) have been commonly used to treat endodontic postoperative pain. The purpose of this study was to address what is the comparative efficacy of NSAIDS compared with nonnarcotic analgesics or placebo in reducing postoperative pain and the incidence of adverse events.    

At the conclusion, participants should be able to:

  • Discuss the comparative efficacy of NSAIDs alone or in combination with other analgesics and other non-narcotic drugs for postoperative endodontic discomfort in patients who present with pretreatment pain.
  • Describe the systematic review and meta-analysis process used to evaluate the available literature.
  • Evaluate the evidence for ibuprofen and ibuprofen plus acetaminophen combinations to provide greater pain relief than placebo after orthograde endodontic treatment.

1.0 CE hour 


Open to download resource.
Open to download resource.
7 Questions
CE Test
5 Questions  |  Unlimited attempts  |  4/5 points to pass
5 Questions  |  Unlimited attempts  |  4/5 points to pass
1.00 CE credit  |  Certificate available
1.00 CE credit  |  Certificate available

Christine M. Sedgley, B.D.S., M.D.S., M.D.Sc., Ph.D

Dr. Christine Sedgley is Professor and Chair, Department of Endodontology, Oregon Health Science University. She is a Diplomate of the American Board of Endodontics. She has more than 70 research and chapter publications and has participated in over 150 continuing education and research presentations worldwide. Dr. Sedgley is an Associate Editor for the Journal of Endodontics.

Elizabeth A. Smith, D.D.S.

J. Gordon Marshall, D.M.D.

Shelley S. Selph, M.D., M.P.H.

Dale R. Barker, D.D.S