Outcome of Endodontic Microsurgery Using Mineral Trioxide Aggregate or Root Repair Material as Root-end Filling Material: A Randomized Controlled Trial with Cone-beam Computed Tomographic Evaluation

5 (1 vote)

CE Hours: 1.0 CE hour 

The purpose of this randomized clinical trial was to evaluate healing after endodontic microsurgery (EMS) using mineral trioxide aggregate (MTA) versus EndoSequence root repair material (RRM; Brasseler, Savannah, GA) as root-end filling materials.

At the conclusion, participants should be able to:

  • Evaluate the outcome after Endodontic Microsurgery (EMS) according to Penn 3-D Evaluation Criteria
  • List prognostic factors affecting EMS outcome
  • Describe outcome evaluation differences between PA and CBCT healing


Open to download resource.
Open to download resource.
7 Questions
CE Test
5 Questions  |  Unlimited attempts  |  4/5 points to pass
5 Questions  |  Unlimited attempts  |  4/5 points to pass
1.00 CE credit  |  Certificate available
1.00 CE credit  |  Certificate available

Chafic Safi, D.MD, M.Sc., FRCD

Dr. Chafic Safi received the Penn Endo presentation award in 2014 and lectured at the Penn Endo Global Symposium, at the McGill Endodontics Symposium and at the American Association of Endodontics Annual Meeting in 2016. He is a Fellow of the Royal College of Dentists of Canada and is currently board eligible for the American Board of Endodontics. Dr. Safi completed his D.M.D. at Université de Montréal in 2012. He then pursued postgraduate residency in endodontics at the University of Pennsylvania in 2015 where he also completed a master's of science in oral biology researching the outcome of endodontic microsurgery and factors affecting prognosis. Dr. Safi is a faculty lecturer at McGill University and remains faculty at the University of Pennsylvania as an adjunct assistant professor. He lives in Montreal, and is the founder of Centre Endodontique Saint Laurent where his main practice is. Dr. Safi is also a certified lecturer and member of Real World Endo.

Meetu R. Kohli, B.D.S, D.M.D.

Dr. Meetu Ralli Kohli is the Director for Continuing Education and International Visiting Scholar Program at the University of Pennsylvania, School of Dental Medicine, Endodontic department. Dr. Kohli earned her B.D.S. degree from Government Dental College, Bangalore, India. She pursued her D.M.D. degree as well as specialty training in Endodontics at the University of Pennsylvania, USA. During the course of her training she received the esteemed Louis I Grossman award, the Samuel R. Rossman scholarship and the Sherrill Ann Siegel award & scholarship for demonstrating excellence in patient care, clinical skills and research. She is on the Scientific Advisory Board as a reviewer for Journal of Endodontics, International Endodontic Journal and Quintessence International. Dr. Kohli has published in national and international peer reviewed journals and has contributed in books on microsurgical retreatment. She is the associate editor of the Microsurgery in Endodontics atlas. Her publications have received and have been recognized as the best clinical research paper by JOE. She has served on the AAE’s Constitution and Bylaws committee and currently serves in the Research and Scientific Affairs Committee. She is a Diplomate of the American Board or Endodontics. Dr. Kohli also maintains a part-time private practice in Pennsylvania, U

Samuel I. Kratchman, D.M.D.

Dr. Samuel Kratchman Dr. Sam Kratchman was born and raised in New York. He received a B.S. in Biology and a D.M.D. both from Tufts University in Boston, Massachusetts. Sam then entered the University of Pennsylvania, where he received a certificate of endodontics, and currently serves as an Associate Professor of Endodontics and the Assistant Director of Graduate Endodontics, in charge of the microsurgical portion of the program. Dr. Kratchman has authored several articles and chapters on endodontics and intentional replantation for the Microsurgery in Endodontics textbook, and the Dental Clinics of North America. He also developed a patented instrument called the S Kondenser for the obturation of root canals. Both Main Line Today and Doctor of Dentistry magazines honored Dr. Kratchman as the cover story for their “Best of “ issues. Dr. Kratchman lectures on several topics of endodontics throughout the United States, Europe, Scandinavia, South America, Canada and Asia. He also maintains two private practices, limited to endodontics, in Exton and West Chester Pennsylvania.

Frank C. Setzer, D.M.D., Ph.D., M.S.

Dr. Setzer graduated from the Dental School of the Friedrich- Alexander-University Erlangen-Nuremberg, Germany, in 1995, where he also received his doctoral degree in 1998. He pursued his endodontic specialty training at the University of Pennsylvania after working for nine years in a multi-specialist private practice as associate and partner. Dr. Setzer graduated from the endodontic program of the University of Pennsylvania in 2006, receiving the Louis I Grossman Postdoctoral Student Award in Endodontics. He earned a Master of Science in Oral Biology and a DMD degree in 2008 and 2010, respectively. Dr. Setzer serves as the Clinic Director and Pre-Doctoral Program Director at the Department of Endodontics of the University of Pennsylvania. Dr. Setzer lectures on several topics of endodontics throughout the United States, Europe, South America, and Asia. He has authored articles on endodontics in peer-review journals and serves as Associate Editor for Endodontics for Quintessence International and, amongst other journals, on the scientific advisory board of Journal of Endodontics, International Endodontic Journal and Journal of the American Dental Association.

Bekir Karabucak, D.M.D., M.S.

Dr. Karabucak is Associate Professor/Clinician Educator, Interim Chair and Director of post-graduate program in the Department of Endodontics. Dr. Karabucak serves as director of Advanced Dental Education in the School of Dental Medicine. After earning his dental degree from Istanbul University School of Dental Medicine in 1993, Dr. Karabucak completed his endodontic postgraduate training at the Department of Endodontics at Penn, where he also received his Masters in Oral Biology in 1998. He later earned his DMD degree from Penn Dental Medicine in 2002. He’s the attending endodontist at the Children’s Hospital of Philadelphia since 2005. He is a Diplomate of the American Board of Endodontics. He lectured at national and international conferences and also serves as a reviewer for the Journal of Endodontics.

The authors thank Dr Fouad Al-Malki, Ms Anya Kohli in making the illustrations and figures for the article, and Christel Chehoud for help with statistical analysis.

Supported and conducted independently by the Department of Endodontics, University of Pennsylvania, Philadelphia, PA.

The authors deny any conflicts of interested related to this study