S-4 Biologic Concepts of Guided Tissue Regeneration in Endodontic Surgery

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S-4 Biologic Concepts of Guided Tissue Regeneration in Endodontic Surgery


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Guided tissue regeneration represents implantation of acellular matrices into the host to guide repopulation of desirable cells. The concept of GTR technique in endodontic surgery is derived from that in periodontal therapy. However, GTR technique in periodontal therapy is different from that in endodontic surgery. GTR technique using barrier membranes or bone grafts in periodontal therapy is directed at regenerating damaged cementum, periodontal ligament and alveolar crest bone by excluding gingival fibrous connective tissue and epithelium from occupying the denuded root surface. GTR technique in endodontic surgery is presumed to improve regeneration of damaged periapical bone by excluding fibrous connective tissue from occupying a periapical lesion, thus avoiding scar tissue formation. Studies suggested if large inflammatory periapical lesions eroded both buccal and palatal (lingual) bone plates, GTR technique would be recommended in order to prevent scar tissue formation following endodontic surgery. GTR technique may improve periapical bone wound healing but will not enhance the success of endodontic surgery. Success of endodontic surgery is attributed to elimination of infection and not to application of GTR technique. 


At the conclusion, participants should be able to:

  • Describe what is guided tissue regeneration.
  • Define indications of GTR technique in endodontic surgery.
  • Recognize that GTR technique would not improve success of endodontic surgery withouty elimination of infection.

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Louis Lin, BDS, DMD, PhD

Dr. Louis M. Lin graduated from Chung Shan Medical University School of Dentistry, Taiwan. He then went to University of Tokyo University Hospital, Japan to receive postgraduate training in Oral Surgery. He continued to pursue graduate study in Pathology at University of Oklahoma Medical Center, Oklahoma, USA and obtained a PhD degree in Pathology. He completed Oral Pathology residency at Louisiana State University School of Dentistry, Louisiana, USA. He received a Doctor of Dental Medicine degree from Rutgers University School of Dentistry, New Jersey, USA. He also completed Postgraduate Education in Endodontics at University of Connecticut School of Dental Medicine. Connecticut, USA. Dr. Lin has been Director of Postgraduate Education in Endodontics at Rutgers University School of Dentistry, New Jersey, University of California School of Dentistry at Los Angeles, California, and New York University College of Dentistry, New York. He has also been Chair of Department of Endodontics at Rutgers University School of Dentistry, New Jersey, and University of California School of Dentistry, California.

Louis M. Lin, D.M.D., B.D.S., Ph.D.

I declare that I have no proprietary, financial, or other personal interest of any nature or kind in any product, service, course, and/or company, or in any firm beneficially associated therewith, that will be discussed or considered during the proposed presentation.