SP-7 Minced Pulp Tissue as Source of Pulpal MSCs

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CE: 1.5

Pulp tissue regeneration is becoming a reality after discovery of mesenchymal stem cells (MSCs) residing in the pulp tissues. Revascularization has become a standard of care for immature cases with pulpal necrosis and apical abscess, yet presents with some complications including intracanal calcifications. To regenerate bone fide pulp-dentin complex, cell-based approaches have been devised, although limited by complexities with in vitro cell culture. To circumvent these issues, we investigated the use of minced pulp tissues as a direct source of pulpal MSCs for tissue regeneration. We characterized the phenotype of cells explanted from minced pulp, namely minced pulp-derived MSCs (MP-MSCs), compared with dental pulp stem cells (DPSC) established from pulp tissues by enzyme digestion and explored the use of these cells for pulp-dentin regeneration. This presentation will highlight the challenges faced with revascularization and the potential use of MP-MSCs for pulp regeneration, through novel concept of pulp tissue grafting.

At the conclusion, participants should be able to:

  • Discuss the successful outcomes and limitations of revascularization.
  • Describe the current state of knowledge dealing with cell-based endodontic regenerative therpaies.
  • Recognize the concept of pulp tissue grafting.
Components visible upon registration.

Mo Kang, D.D.S., M.S., Ph.D.

SP-7 Minced Pulp Tissue as Source of Pulpal MSCs

Dr. Kang is Professor and Chairman of the Section of Endodontics at the UCLA School of Dentistry. He holds Jack Weichman Endowed Chair at UCLA. Dr. Kang received his DDS and PhD from UCLA in 2001 and completed his endodontic training there in 2003. He has received numerous honors for his research and scholarship, including the Edward E. Hatton award from the American and International Association for Dental Research and distinguished scientist awards. Dr. Kang’s research focuses on the mechanisms of pulpal inflammation, tissue regeneration, as well as cancer biology. He currently serves as Associate Editor of the Journal of Endodontics and review board for Journal of Dental Research. Dr. Kang is an internationally recognized scholar and lecturer with his expertise in clinical endodontics, bioceramics, pulp regeneration, and other basic science topics. He maintains active private practice limited to Endodontics.

Mo K. Kang, D.D.S., M.S., Ph.D.


I declare that I have no proprietary, financial, or other personal interest of any nature or kind in any product, service, course, and/or company, or in any firm beneficially associated therewith, that will be discussed or considered during the proposed presentation.