A Novel Self-Mineralizing Antibacterial Tissue Repair Varnish to Condition Root-end Dentin in Endodontic Microsurgery

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CE Hours: 1.0

Description: A novel 2-part varnish system containing chitosan nanoparticles (part 1) and chitosan-grafted hydroxyapatite precursor nanocomplex (part 2) was developed to condition the root-end dentin using the principle of biomineralization while rendering both antimicrobial efficacy and bioactivity. This in vitro study aimed to characterize and assess the effectiveness of the chitosan nanoparticles and chitosan-grafted hydroxyapatite precursor nanocomplex containing self-mineralizing antibacterial tissue repair varnish to condition as well as seal rootend dentin during endodontic microsurgery.

  • Describe the main properties of the varnish system developed for root end-dentin
  • Discuss the mechanism of action of the varnish system on root-end dentin
  • List the benefits of root-end dentin biomineralization


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    Open to download resource. Published 6/1/2021
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    Gillian Landzberg, DDS, MSc,*

    Hebatullah Hussein, BDS, MDS,

    Anil Kishen, B.D.S., M.D.S., Ph.D.

    Dr. Anil Kishen is the Dean, Zwingenberger Decanal Chair, and Professor of Endodontics at the Faculty of Dentistry, University of Toronto. He also holds a Tier 1 Canada Research Chair in Oral Health Nanomedicine.

    Dr. Kishen has received numerous honors, including the 2020 Louis I. Grossman Award from the American Association of Endodontists, the 2023 National Dental Research Award (CADR/ACFD), the W. W. Wood Award for excellence in dental education, and the Enterprise Challenge Innovator Award in Singapore.

    He has published over 300 journal articles, 24 book chapters, and three books, and holds 12 patents. He has delivered more than 200 invited lectures globally and serves as Associate Editor for several leading journals, including the Journal of Endodontics.

    His research, funded by federal and foundation grants, focuses on wound healing, nanoparticle-guided tissue engineering, and microbe–host cell interactions.