Anesthetic Efficacy of Combination of 4% Prilocaine/2% Lidocaine with Epinephrine for the interior alveolar nerve BlockL

5 (1 vote)

CE Hours: 1.0 CE hour 

Description: Prilocaine plain has a high pH and concentration (4%), which could decrease the pain of injection and increase success. The purpose of this study was to compare pain associated with anesthetic solution deposition and the degree of pulpal anesthesia obtained with the combination of prilocaine and lidocaine versus a lidocaine and lidocaine combination when used for inferior alveolar nerve blocks (IANBs).

At the conclusion, participants should be able to:

  • Evaluate if the combination 4%prilocaine/2% lidocaine with epinephrine resulted in an increase in anesthetic success of the inferior alveolar nerve block when compared to two cartridges of 2% lidocaine with epinephrine
  • Describe if 4% prilocaine resulted in less anesthetic solution deposition pain.
  • Discuss the side-effects when prilocaine is used clinically.


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Open to download resource.
7 Questions
CE Test
5 Questions  |  Unlimited attempts  |  4/5 points to pass
5 Questions  |  Unlimited attempts  |  4/5 points to pass
1.00 CE credit  |  Certificate available
1.00 CE credit  |  Certificate available

Oliva Cook, DMD, MS

Dr. Olivia Cook is a born native of Jackson, MS.  After graduating high school, she continued her undergraduate studies at Ole Miss.  Dr. Cook then completed her dental school training at The University of Mississippi in Jackson and her endodontic specialty training at The Ohio State University in Columbus, Ohio.  During her post-doctoral training, Dr. Cook was extensively trained in local anesthesia and pain management with an emphasis on emergency patients.  Dr. Cook then moved back to Madison, MS upon completion of her residency program. 

Dr. Cook is a member of the American Dental Association, the Mississippi Dental Association, and the American Association of Endodontist.  In her free time, she enjoys being an active participant in her church and spending time with her husband and daughter.

John Nusstein, D.D.S., M.S.

Dr. John Nusstein is a tenured Professor and the Chair of the Division of Endodontics at The Ohio State University College of Dentistry in Columbus, Ohio.

Melissa Drum, D.D.S., M.S.

Dr. Melissa Drum is an endodontist and full-time educator. Dr. Melissa Drum is the Graduate Program Director at The Ohio State University College of Dentistry.

Sara Fowler, D.M.D. M.S.

Dr. Sara Fowler is a member of the Inaugural Class of the University of Nevada Las Vegas School of Dental Medicine graduating class of 2006. A native Ohioan, she returned to Ohio to complete the General Practice Residency program at The Ohio State University. She then served as the Endodontic Division’s Postgraduate Fellow before going on to Advanced Endodontic training at Ohio State where she earned her M.S. in 2010. Following her endodontic program, she practiced full-time before deciding that academia was her true calling. As an Assistant Professor, she is currently serving as the Director of Predoctoral Endodontics and the Emergency Dental Clinic at The Ohio State University College of Dentistry.

Al Reader D.D.S., M.S.

Dr. Al Reader is a Professor in the Division of Endodontics and is a previous program director of Advanced Endodontics at the The Ohio State University.

John Draper, MS, PhD

Dr. John Draper has a PhD and MS in statistics from Ohio State and is a senior lecturer in the Department of Management Sciences. He provided the statistical support for this research project.