Anesthetic Efficacy of Gow-Gates, Vazirani-Akinosi, and Mental Incisive Nerve Blocks for Treatment of Symptomatic Irreversible Pulpitis: A Systematic Review and Meta-analysis with Trial Sequential Analysis

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CE Hours: 1.0 CE hour 

Description: This systematic review compared the anesthetic efficacy between Gow-Gates (GG), Vazirani-Akinosi (VA), and mental incisive (MI) nerve blocks (NBs) with inferior alveolar nerve blocks (IANBs) in mandibular teeth with irreversible pulpitis using meta-analysis and trial sequential analysis (TSA).

At the conclusion, participants should be able to:

  • Discuss the different anesthetic techniques used to anesthetize mandibular teeth 
  • Discuss the anesthetic efficacy between different techniques used to anesthetize mandibular teeth 
  • Discuss the quality and strength of evidence in this systematic review


Open to download resource.
Open to download resource.
7 Questions
CE Test
5 Questions  |  Unlimited attempts  |  4/5 points to pass
5 Questions  |  Unlimited attempts  |  4/5 points to pass
1.00 CE credit  |  Certificate available
1.00 CE credit  |  Certificate available

The authors deny any conflicts of interest related to this study.

Venkateshbabu Nagendrababu, BDS, MDS, PhD

Hany Mohamed Aly Ahmed, B.D.S., H.D.D. (Endo), Ph.D.

Shaju Jacob Pulikkotil, BDS, MDS, PhD

Sajesh K. Veettil, MPharm,

Lalli Dharmarajan, BDS

Frank C. Setzer, D.M.D., Ph.D., M.S.

Dr. Setzer graduated from the Dental School of the Friedrich- Alexander-University Erlangen-Nuremberg, Germany, in 1995, where he also received his doctoral degree in 1998. He pursued his endodontic specialty training at the University of Pennsylvania after working for nine years in a multi-specialist private practice as associate and partner. Dr. Setzer graduated from the endodontic program of the University of Pennsylvania in 2006, receiving the Louis I Grossman Postdoctoral Student Award in Endodontics. He earned a Master of Science in Oral Biology and a DMD degree in 2008 and 2010, respectively. Dr. Setzer serves as the Clinic Director and Pre-Doctoral Program Director at the Department of Endodontics of the University of Pennsylvania. Dr. Setzer lectures on several topics of endodontics throughout the United States, Europe, South America, and Asia. He has authored articles on endodontics in peer-review journals and serves as Associate Editor for Endodontics for Quintessence International and, amongst other journals, on the scientific advisory board of Journal of Endodontics, International Endodontic Journal and Journal of the American Dental Association.