Differentially Expressed Genes in Dental Pulp Tissues of Individuals With Symptomatic Irreversible Pulpitis With and Without History of COVID-19
CE Hours: 1.0
Description: Increased levels of proinflammatory markers have been reported in tissues of individuals with Coronavirus Disease 2019 (COVID-19). We hypothesize that inflamed dental pulp tissues of individuals with previous history of COVID-19 may present a differential inflammatory gene expression profile in comparison with individuals who never had COVID-19.
At the conclusion of this article, the reader will be able to:
- Explain molecular markers of inflamed dental pulp tissue in patients with and without history of COVID-19
- Identify novel biological pathways involved in dental pulp inflammation
- Describe how past COVID-19 disease status may impact dental pulp inflammation
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Han Na Cho, DMD, MSD
Dr. Han Na Cho graduated from Mount Holyoke College in Massachusetts with a Bachelor of Arts in Biology and a minor in Chemistry. She then earned her Doctor of Dental Medicine degree at the University of Pennsylvania School of Dental Medicine in Philadelphia. After graduating from dental school, she completed a General Practice Residency (GPR) at Flushing Hospital Medical Center in New York and continued her education at the University of Texas Health Science Center at Houston, where she earned her specialty certificate in Endodontics and a Master of Science in Dentistry degree. Dr. Cho is an American Board of Endodontics eligible endodontist and is currently an active member of the American Association of Endodontists, American Dental Association, Texas Dental Association and Greater Houston Dental Society. She is currently working as an associate in a private practice in Houston.
Leticia Chaves de Souza, DDS, MS, PhD
Cleverick Johnson, DDS, MS
John R. Klein, PhD
Timothy C. Kirkpatrick, DDS
Dr. Timothy Kirkpatrick is a professor in the Department of Endodontics at UTHealth School of Dentistry at Houston, where he also serves as the Department Chair and Program Director of the Advanced Education in Endodontics Program.
Renato M. Silva, D.D.S., M.S., P.h.D.
Dr. Silva received his DDS from the University Gama Filho, Rio de Janeiro, Brazil, in 1994. He received his endodontic certificate from both Brazil (University Gama Filho) and US (University of Texas Health Science Center at Houston). Dr. Silva received his MS (2002) in Endodontics and PhD (2006) degree in Oral Sciences from University of Sao Paulo, Brazil. He also completed a postdoctoral fellowship in Human Molecular Genetics at the University of Pittsburgh. Dr. Silva worked as an Assistant Professor at University of Pittsburgh from 2007 to 2011, and Associate/Professor/Department Chair at University of Texas at Houston from 2011 to 2021. Dr. Silva is currently a Professor and Chair of the Department of Endodontics at The University of Pittsburgh, School of Dental Medicine. Dr. Silva has edited a textbook about Endodontic retreatment and published several peer-reviewed articles in the field of Endodontics and Human Genetics. He is a board-certified endodontist and maintains a faculty practice limited to Endodontics.
Speaker Disclosure
I declare that I have no proprietary, financial, or other personal interest of any nature or kind in any product, service, course, and/or company, or in any firm beneficially associated therewith, that will be discussed or considered during the proposed presentation.
Ariadne Letra, D.D.S., M.S., P.h.D.
Dr. Ariadne Letra is a tenured professor of Oral and Craniofacial Sciences and Endodontics, and a member of the Center for Craniofacial and Dental Genetics at the University of Pittsburgh School of Dental Medicine.
Dr. Letra’s research focuses on gene discovery and functional genomic characterization approaches to understand the etiology of complex craniofacial and oral traits and conditions such as cleft lip/palate, tooth agenesis, and apical periodontitis. Another aspect of Dr. Letra’s work focuses on identifying host factors contributing to the interconnectedness between oral and systemic health and disease.
Dr. Letra has been the principal investigator for several NIH and AAE foundation grants and has served in various NIH study sections. Her residents have also been recipients of numerous AAE Resident Research grant awards and placed among the top ten winners of the AAE/Dentsply Resident Research Presentation Awards for the last ten years.
Dr. Letra’s work has been recognized through prestigious awards including the 2020 Journal of Endodontics Best Paper in Clinical Research Award. Her work was also featured on the cover of the Journal of Endodontics, Journal of Dental Research, and Orthodontics and Craniofacial Research Journal. Dr. Letra is a recipient of the distinguished 2018 AADR/SCADA Burton C. Borgelt Faculty 160 peer-reviewed articles, 5 book chapters, and numerous abstracts and publications in the media. She is an associate editor of the Journal of Endodontics, and a member of the editorial board of numerous medical and dental journals including the Journal of Dental Research, Journal of Dental Research Clinical and Translational Research, American Journal of Human Genetics, among others.
Dr. Letra is currently Chair of the AAE Research and Scientific Affairs Committee.
Disclosure
I declare that I have no proprietary, financial, or other personal interest of any nature or kind in any product, service, course, and/or company, or in any firm beneficially associated therewith, that will be discussed or considered during the proposed presentation.
