FEP-12 Stem Cell Technology: Twenty-four Years After Discovery of Dental Pulp Stem Cells
CE Hours: 1.25
Description: The discovery of dental stem cells (DSCs) in the 2000s has led to the emergence of regenerative endodontics and promoted recent endeavor on vital pulp therapy. The knowledge on dental stem cells particularly dental pulp stem cells (DPSCs) and stem cells of apical papilla (SCAP) has helped the establishment of two categories of clinical approaches to regain the vitality of pulp. One is stem-cell based therapy that involves implanting exogenously processed stem cells into the root canal space, termed cell-based regenerative endodontic therapy (CB-RET). The other is the known revitalization or also termed revascularization, that does not involve the delivery of exogenously processed stem cells into the canals therefore is termed cell-free regenerative endodontic therapy (CF-RET). The various animal and human clinical studies have shown that both CB-RET or CF-RET increase root thickness and/or allow further root development, as well as eliminating endodontic pathosis with high clinical success rates.
Learning Objectives:
- List the types of oral stem cells that have been studied.
- Provide an overview of cell-based and cell-free therapy for regenerative endodontics.
- Relate the importance of dental pulp stem cells and stem cells of apical papilla to vital pulp therapy.
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George T-J. Huang, D.D.S., M.S.D., D.Sc
Dr. Huang is a board certified endodontist, currently Professor and Director for Stem Cells and Regenerative Therapies, Department of Bioscience Research at UTHSC, College of Dentistry. He is the former Chair/Herbert Schilder Professor in Endodontics, at Boston University, also a former Chair in Endodontics at Columbia University. Dr. Huang has published ~180 research articles, abstracts, review articles, including papers in Stem Cells, Stem Cells and Development, Stem Cell Research and Therapy, Stem Cell Reviews and Reports, Tissue Engineering, Regenerative Medicine, Infection and Immunity, Human Gene Therapy, Journal of Dental Research, Journal of Endodontics, etc; and 19 book chapters in books such as Ingle’s Endodontics, Cohen’s Pathways of the Pulp, Endodontic Microbiology, Principles of Regenerative Medicine, Tissue Engineering and Regenerative Dentistry, Tissue-Specific Stem Cell Niche, Material-Tissue Interfacial Phenomena, etc; and co-edited with Dr. Irma Thesleff and wrote chapters for the text book “Stem cells, craniofacial development and regeneration”, in 2013, published by Wiley-Blackwell. His research has been funded by various sources including NIH and AAE Foundation. His current research interest is in the area of stem cells and regenerative medicine.
Disclosure(s): No financial relationships to disclose