I-10 Regenerative Protocols and Tissue Engineering in Endodontics Where Are We and What Is Next?

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CE Hours: 1.5

Description: Regenerative endodontics has been recognized as a unique protocol in the practitioner's armamentarium to harness the regenerative potential of periapical tissues, facilitating continued root development and regeneration of the dentin-pulp complex, particularly in immature necrotic teeth. Preclinical and clinical research have significantly enhanced our understanding of the key factors contributing to success and failure. In this presentation, we will share the most recent data and protocols for regenerative endodontics, as well as emerging tissue engineering technologies aimed at regenerating lost tissues. Dr. Botero will discuss the clinical rationale and protocols in regenerative endodontics, along with clinical evidence, outcomes, and limitations of these protocols. Dr. Bottino will then explore the current status and clinical potential of tissue engineering in endodontics, including applications in regenerative endodontics and vital pulp therapy, ongoing materials and technologies, preclinical and translational research, as well as barriers and opportunities.

Learning Objectives:  

  • Describe the fundamental principles and clinical protocols of regenerative endodontic procedures (REP), with emphasis on the latest evidence and outcomes and identify and analyze the clinical factors that influence the success and limitations of REP, including practical considerations for implementation and follow-up.
  • Compare and contrast conventional REP with modern tissue engineering technologies in terms of clinical potential, translational hurdles, and future impact on patient care.
  • Compare and contrast conventional REP with modern tissue engineering technologies in terms of clinical potential, translational hurdles, and future impact on patient care. the audience will be also able to recognize the key challenges and opportunities in advancing from current regenerative protocols toward fully functional tissue engineering solutions for endodontic regeneration.

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    I-10 Regenerative Protocols and Tissue Engineering in Endodontics Where Are We and What Is Next?
    Recorded 04/17/2026  |  90 minutes
    Recorded 04/17/2026  |  90 minutes
    Evaluation
    14 Questions
    CE Test
    5 Questions  |  Unlimited attempts  |  4/5 points to pass
    5 Questions  |  Unlimited attempts  |  4/5 points to pass
    Certificate
    1.50 CE credits  |  Certificate available
    1.50 CE credits  |  Certificate available
    Tatiana M. Botero, D.D.S., M.S.

    Tatiana M. Botero, D.D.S., M.S.

    TATIANA MA. BOTERO D., DDS, MS Diplomate American Association of Endodontics Clinical Professor Cariology, Restorative Sciences and Endodontics Department School of Dentistry, University of Michigan Dr. Botero received her dental degree from CES University in Medelli­n, Colombia. She then completed specialty training in Endodontics at Pontificia Universidad Javeriana in Bogotá, Colombia, and went on to earn an advanced Specialty Certificate in Endodontics from the University of Michigan. Dr. Botero began her academic career as a Clinical Assistant Professor at CES University, alongside managing her private practice in Colombia. In 2001, she joined the University of Michigan, where she is currently a full-time Clinical Professor, teaching Endodontics to both undergraduate and graduate students. She served as director of the dental postgraduate fellowship program in Endodontics from 2017 to 2022, and continues to practice Endodontics at a private dental clinic in Michigan. In 2012, Dr. Botero became a Diplomate of the American Board of Endodontics. She joined the Regenerative Endodontic Committee of the American Association of Endodontists in 2013, served as chair from 2014 to 2020, and resumed that role for 2024-2025. She was also president of the Pulp Biology and Regeneration Group (2016-2017) of both the American Association for Dental Research and the International Association for Dental Research. Dr. Botero has authored and co-authored numerous peer-reviewed scientific articles and book chapters.

    Disclosure(s): No financial relationships to disclose


    Marco Bottino, D.D.S., Ph.D., M.Sc.

    Marco Bottino, D.D.S., Ph.D., M.Sc.

    Dr. Bottino is the Robert W. Browne Endowed Professor of Dentistry in the Department of Cariology, Restorative Sciences, and Endodontics (CRSE) at the University of Michigan School of Dentistry (U-M). He is currently the Director of Research in CRSE and the Director of the Postgraduate Program in Regenerative Dentistry at U-M. As a principal investigator, Marco has received research grants related to regenerative medicine from the National Institutes of Health (NIH), foundations, and private industry. He has received the International Association for Dental Research (IADR) Centennial Emerging Leader Award and was the recipient of Young Investigator Awards from the IADR Pulp Biology and Implantology Research Groups and a prestigious Mentored Clinical Scientist Research Career Development Award from the National Institute for Dental and Craniofacial Research at NIH. He also serves as the reviewer for more than 30 journals in regenerative medicine and biomaterials, and, between 2018 and 2023, served as a standing member of the Musculoskeletal and Tissue Engineering (MTE) study section for the NIH. Marco is an elected Fellow of the Academy of Dental Materials (ADM) and a board member. The present study was conducted under Dr. Bottino's surveillance.

    Disclosure(s): No financial relationships to disclose