Mesenchymal Stem Cell Marker Expression in Periapical Abscesses

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CE Hours: 1.0 CE hour

There is evidence that acute periapical lesions present a greater potential for cyst formation. Recently, it was found that these lesions have cells with characteristics of pluripotent stem cells, which may influence cyst development. However, a more complete phenotype investigation of stem cells in a specific sample of periapical abscesses is required. The aim of this study was to analyze the immunohistochemical expression of mesenchymal stem cell (MSC) markers in periapical abscesses and to evaluate differences in their expression in relation to acute and chronic periapical lesions.

At the conclusion, participants should be able to:

  • Describe the pathological pathway of cyst formation
  • Explain  the importance of characterizing stem cells present in the periapical lesions
  • Discuss the relationship between acute periapical abscess and cyst formation


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Carlos Estrela, DDS, MSc, PhD

Paulo Otavio Carmo Souza, DDS

Mateus Gehrke Barbosa, DDS

Artur Aburad de Carvalhosa, DDS, MSc, PhD

Aline Carvalho Batista, DDS, MSc, PhD

Decio dos Santos Pinto Junior, DDS, MSc, PhD,

Fernanda Paula Yamamoto-Silva, DDS, PhD

Brunno Santos de Freitas Silva, DDS, MSc, PhD

The authors deny any conflicts of interest related to this study.