MicroRNAs Markedly Expressed in Apical Periodontitis Cooperatively Regulate Cytokines and Growth Factors Promoting an Anti-inflammatory Response
CE Hours: 1.0
Description: MicroRNAs have been shown to play a role in the pathogenesis of apical periodontitis. Upregulation of miR-10a-5p and downregulation of miR-891a-5p were previously reported in apical periodontitis samples. This study aims to perform a functional characterization of miR-10a-5p, investigating its capacity to regulate the expression of inflammatory cytokines and growth factors, as well as a possible co-regulation mechanism with miR-891a-5p in the development of apical periodontitis.
At the conclusion of this article, the reader will be able to:
- List a few microRNAs that are associated with apical periodontitis.
- Identify key cytokines and growth factors in apical periodontitis that are regulated by microRNAs.
- Describe how microRNAs regulate apical periodontitis in a synergistic fashion.
|Access Date||Quiz Result||Score||Actions|
Zhen Shen, D.M.D., M.s.D., P.h.D.
Dr. Zhen Shen received his PhD degree in Cell and Developmental Biology from the University of Illinois, Urbana-Champaign (2012), and the DMD degree (Magna Cum Laude) from Harvard School of Dental Medicine (2019). He received his certificate and MSD degree in Endodontics from the University of Texas Health Science Center at Houston School of Dentistry (2021) and became a diplomate of the American Board of Endodontics in 2022. Dr. Shen is currently a clinical assistant professor at the University of Texas Health Science Center at Houston School of Dentistry and also works in private practice. Dr. Shen has published several peer-reviewed articles in the field of Endodontics and Cell Biology.
Ariadne Letra, D.D.S., M.S., P.h.D.
Ariadne Letra is a tenured professor of Oral and Craniofacial Sciences and Endodontics, and a member of the Center for Craniofacial and Dental Genetics at the University of Pittsburgh School of Dental Medicine. She obtained her DDS degree from Fluminense Federal University, a MS in Endodontics at State University of Rio de Janeiro, and a PhD in Oral Biology from the University of Sao Paulo, Brazil. She moved to the US to pursue a postdoctoral fellowship in Human Molecular Genetics at the University of Pittsburgh, where she remained as Assistant Professor until 2011. From August 2011 to May 2022, Dr. Letra was on the faculty at UTHealth School of Dentistry in Houston before returning to the University of Pittsburgh in June 2022.
The Letra Lab research focuses on cellular and molecular basis of pulpal and periapical disease, and craniofacial anomalies such as cleft lip/palate and dental anomalies. Her work also focuses on investigating the interconnectedness between oral and systemic health and disease. Letra has been the principal investigator on several NIH and AAE foundation grants. Her residents have also been recipients of numerous AAE Resident Research grant awards and placed among the top ten winners of the AAE/Dentsply Resident Research Presentation Awards for the last ten years.
Letra’s work has been recognized through prestigious awards including the 2020 Journal of Endodontics Best Paper in Clinical Research Award, first place in the IADR Hatton Competition (2016) and the AADR/SCADA Burton C. Borgelt Faculty Advisor Award. Her work was also featured on the cover of the Journal of Endodontics, Journal of Dental Research, and Orthodontics and Craniofacial Research Journal. She has authored over 150 peer-reviewed articles, 5 book chapters, and numerous abstracts and publications in the media. She is an associate editor of the Journal of Endodontics, and has served as a member and officer in numerous committees at the AAE, AADOCR, and IADR. She has been member and Chair of the AAE Research and Scientific Affairs Committee in two different terms.
Ideclare that I have no proprietary, financial, or other personal interest ofany nature or kind in any product, service, course, and/or company, or in anyfirm beneficially associated therewith, that will be discussed or consideredduring the proposed presentation.
Renato M. Silva, D.D.S., M.S., P.h.D.
Dr. Silva received his DDS from the University Gama Filho, Rio de Janeiro, Brazil, in 1994. He received his endodontic certificate from both Brazil (University Gama Filho) and US (University of Texas Health Science Center at Houston). Dr. Silva received his MS (2002) in Endodontics and PhD (2006) degree in Oral Sciences from University of Sao Paulo, Brazil. He also completed a postdoctoral fellowship in Human Molecular Genetics at the University of Pittsburgh. Dr. Silva worked as an Assistant Professor at University of Pittsburgh from 2007 to 2011, and Associate/Professor/Department Chair at University of Texas at Houston from 2011 to 2021. Dr. Silva is currently a Professor and Chair of the Department of Endodontics at The University of Pittsburgh, School of Dental Medicine. Dr. Silva has edited a textbook about Endodontic retreatment and published several peer-reviewed articles in the field of Endodontics and Human Genetics. He is a board-certified endodontist and maintains a faculty practice limited to Endodontics.
I declare that I have no proprietary, financial, or other personal interest of any nature or kind in any product, service, course, and/or company, or in any firm beneficially associated therewith, that will be discussed or considered during the proposed presentation.