MicroRNAs Markedly Expressed in Apical Periodontitis Cooperatively Regulate Cytokines and Growth Factors Promoting an Anti-inflammatory Response
CE Hours: 1.0
Description: MicroRNAs have been shown to play a role in the pathogenesis of apical periodontitis. Upregulation of miR-10a-5p and downregulation of miR-891a-5p were previously reported in apical periodontitis samples. This study aims to perform a functional characterization of miR-10a-5p, investigating its capacity to regulate the expression of inflammatory cytokines and growth factors, as well as a possible co-regulation mechanism with miR-891a-5p in the development of apical periodontitis.
At the conclusion of this article, the reader will be able to:
- List a few microRNAs that are associated with apical periodontitis.
- Identify key cytokines and growth factors in apical periodontitis that are regulated by microRNAs.
- Describe how microRNAs regulate apical periodontitis in a synergistic fashion.
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LockedZhen Shen, D.M.D., M.s.D., P.h.D.
Dr. Zhen Shen received his PhD degree in Cell and Developmental Biology from the University of Illinois, Urbana-Champaign (2012), and the DMD degree (Magna Cum Laude) from Harvard School of Dental Medicine (2019). He received his certificate and MSD degree in Endodontics from the University of Texas Health Science Center at Houston School of Dentistry (2021) and became a diplomate of the American Board of Endodontics in 2022. Dr. Shen is currently a clinical assistant professor at the University of Texas Health Science Center at Houston School of Dentistry and also works in private practice. Dr. Shen has published several peer-reviewed articles in the field of Endodontics and Cell Biology.
Ariadne Letra, D.D.S., M.S., P.h.D.
Dr. Letra is a tenured professor in the Departments of Oral and Craniofacial Sciences, Endodontics, and Assistant Dean for Faculty Affairs at the University of Pittsburgh School of Dental Medicine. Her research focuses on the cellular and molecular mechanisms underlying complex craniofacial and oral diseases/disorders, including pulpal/periapical disease. Her laboratory uses gene discovery, genetic analysis, and experimental models to identify genetic variants impacting risk of these disorders/diseases and health outcomes. Her work has been continuously funded by the National Institutes of Health and the American Association of Endodontists Foundation.
Dr. Letra has authored over 120 peer-reviewed articles (h-index=47), 8 book chapters, and numerous abstracts and media publications. Her work has been recognized through prestigious awards, including the Journal of Endodontics Best Paper in Clinical Research Awards (2020 and 2024), first place in the IADR Hatton Award (2016), and the SCADA Burton C. Borgelt Faculty Advisor Award (2018). Her work was featured on the cover of the Journal of Endodontics (JOE), Journal of Dental Research, and Orthodontics and Craniofacial Research Journal. Dr. Letra is an associate editor of the JOE, Endodontics, Chair of the AAE Research and Scientific Affairs Committee, and the AADOCR/IADR Representative to the Publications Committee.
Disclosure
I declare that I have no proprietary, financial, or other personal interest of any nature or kind in any product, service, course, and/or company, or in any firm beneficially associated therewith, that will be discussed or considered during the proposed presentation.
Renato M. Silva, D.D.S., M.S., P.h.D.
Dr. Silva received his DDS from the University Gama Filho, Rio de Janeiro, Brazil, in 1994. He received his endodontic certificate from both Brazil (University Gama Filho) and US (University of Texas Health Science Center at Houston). Dr. Silva received his MS (2002) in Endodontics and PhD (2006) degree in Oral Sciences from University of Sao Paulo, Brazil. He also completed a postdoctoral fellowship in Human Molecular Genetics at the University of Pittsburgh. Dr. Silva worked as an Assistant Professor at University of Pittsburgh from 2007 to 2011, and Associate/Professor/Department Chair at University of Texas at Houston from 2011 to 2021. Dr. Silva is currently a Professor and Chair of the Department of Endodontics at The University of Pittsburgh, School of Dental Medicine. Dr. Silva has edited a textbook about Endodontic retreatment and published several peer-reviewed articles in the field of Endodontics and Human Genetics. He is a board-certified endodontist and maintains a faculty practice limited to Endodontics.
Speaker Disclosure
I declare that I have no proprietary, financial, or other personal interest of any nature or kind in any product, service, course, and/or company, or in any firm beneficially associated therewith, that will be discussed or considered during the proposed presentation.