OS-09 Central Sensitization, Neuropathic Pain and Implications on Endodontic Treatment

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CE Hours: 1.0

Description: Central sensitization is a critical mechanism underlying persistent pain following root canal therapy. It occurs when the central nervous system enters a prolonged state of hyperexcitability, leading to the amplification of pain. This phenomenon contributes to the development of neuropathic pain, which may affect approximately 1-12% of patients after endodontic procedures. One proposed mechanism is deafferentation, where the removal or injury of pulp afferent neurons disrupts normal sensory input. This disruption can trigger maladaptive neuroplastic changes, including activation of glial cells, which perpetuate a hyperexcitable state and reinforce chronic pain pathways. Preventing neuropathic pain begins during endodontic therapy. Minimizing neural trauma, recognizing early signs of sensitization, and applying evidence-based pain management strategies are essential to improving patient outcomes. This lecture aims to clarify central sensitization in endodontic therapy, its relationship with neuropathic pain, and the implications of these occurrences in endodontic treatment.

Learning Objectives:  

  • Identify signs of central sensitization in endodontic patients
  • Define the neurobiological mechanisms linking endodontic procedures to neuropathic pain
  • Implement preventive  strategies to reduce the risk of persistent post-treatment pain
This content will not be available until 07/01/2026 at 12:00 AM (CDT)