AAE Online CE
Progress of Conservative/Regenerative Endodontics
Description: This presentation will review the progress of regenerative endodontics. The definition of regenerative endodontics will be clarified, as will be the term “revitalization” treatment. There are two categories of clinical approaches to regain vitalization of pulp. One is revitalization or also termed revascularization, which does not involve the delivery of processed stem cells into the canals. On the other hand, stem cell-based therapy involves implanting processed stem cells into the root canal space. This approach has shown the regeneration of pulp- and dentin-like tissues in the canal space from animal and human clinical trial studies, suggesting potential practice of true “regenerative endodontics” in the future. The various animal and human clinical studies have shown that the tissues developed in revitalization/revascularization procedures are fibrous connective tissue, some resembling periodontal ligament, not pulp-like, and the mineral tissue as cementum-like or bone, not dentin-like. One outcome regarding revitalization treatment is canal space obliteration by calcification, which accounts for a high percentage of such cases.
At the conclusion, participants will be able to:
- Describe the definition of “conservative endodontics” and revitalization/revascularization procedures.
- Describe the definition of “regenerative endodontics.”
- Describe the progress of “regenerative endodontics” in humans.
George T-J. Huang, D.D.S., M.S.D., D.Sc.
Dr. Huang is a board certified endodontist, currently Professor and Director for Stem Cells and Regenerative Therapies, Department of Bioscience Research at UTHSC, College of Dentistry. He is the former Chair/Herbert Schilder Professor in Endodontics, at Boston University, also a former Chair in Endodontics at Columbia University. Dr. Huang has published more than 170 research articles, abstracts, review articles, including papers in Stem Cells, Stem Cells and Development, Stem Cell Research and Therapy, Tissue Engineering, Regenerative Medicine, Infection and Immunity, Human Gene Therapy, Journal of Dental Research, Journal of Endodontics, etc; book chapters in books such as Ingle’s Endodontics, Cohen’s Pathways of the Pulp, Endodontic Microbiology, Principles of Regenerative Medicine, Tissue Engineering and Regenerative Dentistry, Tissue-Specific Stem Cell Niche, Material-Tissue Interfacial Phenomena, etc; and co-edited with Dr. Irma Thesleff and wrote chapters for the text book “Stem cells, craniofacial development and regeneration”, in 2013. His research has been funded by various sources including NIH and AAE Foundation.