SP-23 Insights into the Endodontic Microbial Consortium
CE Hours: 0.75
Description: Our knowledge on the need for root canal disinfection has improved tremendously over the past decades and yet, much about how endodontic microbiota are organized into sessile communities i.e. biofilms, remains largely unexplored. While we know that these biofilms and their by-products are the principal causes of apical periodontitis, knowledge is still nascent on their cellular and extracellular composition, epigenetic influences that drive compositional changes and most importantly, their functional profiles. We provided the first reports on the role of biological cues relevant to root canal environment and microbial genetics on biofilm matrix development. Driven by this evidence and our findings on inhibiting bacterial communication, the aim of this presentation is to provide an overview and in-depth analysis of the lifestyle, composition and functional characteristics of the root canal microbiome. This presentation will be instrumental in guiding the development of novel approaches against endodontic biofilms and prevention of their recovery.
Learning Objectives:
- Characterize the key properties of biofilms that contribute to their tolerance to antimicrobial agents and disinfection strategies.
- Discuss the current state of knowledge on microbial and functional profiles of the root canal microbiome.
- Describe innovative approaches to suppress and/or eliminate endodontic biofilms.
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Islam Ali, MDS, PhD
Islam Ali is a postdoctoral research fellow at School of Dentistry, Oregon Health & Science University (OHSU), USA. He obtained a master’s degree in Conservative Dentistry & Endodontics and Ph. D. in Microbiology related to Endodontology. He is also a fellow of OHSU diversity in research program to increase the representation of minoritized races/ethnicities in STEM. He also served as a clinical instructor and lecturer of Endodontics at Faculty of Dentistry, Mansoura University, Egypt. His research focuses on endodontic biofilms, polymicrobial interactions, quorum sensing and antibiofilm strategies
Disclosure(s): No financial relationships to disclose
Prasanna Neelakantan, MDS, PhD
Dr. Prasanna Neelakantan is an Associate Professor and Director of Research at the Department of Endodontics at the University of the Pacific, San Francisco, USA. With more than 100 scientific publications in high-impact peer-reviewed journals, Dr. Prasanna’s h-index now stands at 40. He has received many awards and honors including the IADR Innovation in Oral Care Award in 2018 and 2021, and Joseph Lister Award from the IADR in 2018. He has won several awards for teaching at the faculty and university level. He is the Section Editor for Restorative Dentistry and Endodontics, Associate Editor for Frontiers in Cellular and Infection Microbiology, and Frontiers in Oral Health. He also serves on the editorial board of the International Endodontic Journal and is a reviewer for the Journal of Endodontics. His research group focuses on biofilm biology, the development of novel antimicrobials, and its delivery strategies.
Disclosure(s): No financial relationships to disclose