AAE Online CE
SP-23 SCAP: To Regenerate or Not to Regenerate
Stem Cells of the Apical Papilla (SCAP) are important stem cells that modulate root development and are associated with human immature teeth. They have been shown to be important in dentistry and medicine for various regenerative procedures. However, our previous data has demonstrated that these stem cells do not possess good differentiation properties compared to some other dental stem cells, which could possibly contribute to the failures of many Regenerative Endodontic procedures (REPs). This is important to understand as the success of REPs depends on SCAP survival and ability to differentiation among other factors. Hence, it is imperative to identify compounds that can help SCAP differentiate thereby helping our regenerative procedures. N-acetyl cysteine (NAC) is an effective anti-oxidant and differentiation agent. SCAP in combination with NAC has shown promising results helping these cells to survive and differentiate. This differentiation could possibly increase the success rates of REPs.
At the conclusion, participants should be able to:
- Describe the differentiation potential of SCAP.
- Describe the interactions between SCAP and NAC.
- Describe how NAC could contribute to the success of REPs.
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Avina K. Paranjpe, B.D.S., M.S., M.S.D., Ph.D.
Dr. Avina Paranjpe graduated with her BDS (Bachelor of Dental Surgery) degree from the Mumbai University, India in 2000. She was in private practice in Mumbai, India from 2000-2002 after which she obtained her Master’s degree (MS) and a Doctor of Philosophy (PhD) in Oral Biology, Immunology from the University of California, Los Angeles in 2004 and 2007 respectively. Dr. Paranjpe earned her Master of Science in Dentistry (MSD) and Certificate in Endodontics from the University of Washington Graduate Endodontics Program in August 2009 after which she joined the faculty at the University of Washington, School of Dentistry as Assistant Professor. She is a Diplomate of the American Board of Endodontics. Dr. Paranjpe is involved in several ongoing research projects related to dental materials and regenerative Endodontics. She has numerous publications in the area of pulpal regeneration and revascularization, immunology, compatibility of biomaterials.
Avina Paranjpe, B.D.S., M.S.D., M.S., Ph.D.
I declare that I have no proprietary, financial, or other personal interest of any nature or kind in any product, service, course, and/or company, or in any firm beneficially associated therewith, that will be discussed or considered during the proposed presentation.