SP-26 Beyond the Classical Pain Control: Local Analgesia and Pharmacological Synergism

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CE Hours: 0.75

Description: Endodontics has achieved significant progress in both diagnostic procedures and therapeutic approaches. However, the pharmacological management of acute endodontic pain still relies heavily on conventional strategies, predominantly based on systemic monotherapy. Although many of these approaches are clinically effective, their inappropriate or excessive use has contributed to relevant public health issues, particularly due to the misuse and overprescription of certain drugs. In this context, an important question arises: where should the future of acute endodontic pain management be directed? While the development of new analgesic drugs remains a long and expensive process, more accessible short-term alternatives may be considered. These include the combination of existing pharmacological agents to achieve synergistic effects, as well as the design of advanced drug delivery systems aimed at modulating peripheral mechanisms of pain transmission.Multimodal analgesia, through the use of synergistic combinations, allows for a shift in prescription habits-offering enhanced analgesic efficacy, reduced side effects, and shorter treatment durations. Furthermore, the incorporation of hydrogels, nanomaterials, and polymeric scaffolds as carriers for localized, controlled drug release presents a promising alternative that may significantly reduce the need for systemic drug exposure. This lecture explores currently available multimodal analgesic strategies in endodontics and discusses emerging peripheral alternatives that target pain control directly at its source. Such innovations may represent a paradigm shift in how dental professionals approach pharmacological pain management, promoting more precise, efficient, and safer therapeutic protocols.

Learning Objectives:  

  • Recognize the peripheral and central mechanisms involved in the development of endodontic dental pain.
  • Identify the principles to propose effective pharmacological combinations by analyzing multimodal strategies based on analgesic synergism.
  • Identify emerging drug delivery systems as a strategy for the peripheral control of endodontic pain.
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