SP-6 SCAP: Let’s Get Introduced.

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Stem cells of the apical papilla (SCAP) were discovered and characterized about a decade ago as being important stem cells that modulate root development and are associated with human immature teeth. They have been shown to be important in dentistry in regenerative endodontic procedures (REPs). In medicine, they have shown promising results when used in the treatment of spinal cord injuries. However, very little is known about these cells in comparison to some other stem cells in the body. This is important to understand as the success of many REPs could possibly depend on how these cells survive, proliferate, differentiate and interact with other cells and bacteria. Hence, it is imperative to know their characteristics and interactions with the immune system as these could help us identify one possible cause of failure of many regenerative endodontic cases.

At the conclusion, participants should be able to:

  • Describe the characteristics of the SCAP.
  • Describe the interactions between SCAP and the immune system.
  • Discuss factors that should be considered when using stem cells for different procedures.
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Avina K. Paranjpe, B.D.S., M.S., M.S.D., Ph.D.

Dr. Avina Paranjpe graduated with her BDS (Bachelor of Dental Surgery) degree from the Mumbai University, India in 2000. She was in private practice in Mumbai, India from 2000-2002 after which she obtained her Master’s degree (MS) and a Doctor of Philosophy (PhD) in Oral Biology, Immunology from the University of California, Los Angeles in 2004 and 2007 respectively. Dr. Paranjpe earned her Master of Science in Dentistry (MSD) and Certificate in Endodontics from the University of Washington Graduate Endodontics Program in August 2009 after which she joined the faculty at the University of Washington, School of Dentistry as Assistant Professor. She was recently promoted to Professor with Tenure. She is a Diplomate of the American Board of Endodontics and currently serves as a Director on the American Board of Endodontics. Dr. Paranjpe is involved in several ongoing research projects related to dental materials and regenerative Endodontics. She has numerous publications in the area of pulpal regeneration and revascularization, immunology, compatibility of biomaterials. Dr. Paranjpe is a member of the American Association of Endodontists (AAE), American Dental Education Association (ADEA), American Dental Association (ADA) and the International Association of Dental Research (IADR).

Avina K. Paranjpe, B.D.S., M.S., M.S.D., Ph.D.

I declare that I have no proprietary, financial, or other personal interest of any nature or kind in any product, service, course, and/or company, or in any firm beneficially associated therewith, that will be discussed or considered during the proposed presentation.