The Impact of Calcium Silicate–Based and Resin-Based Root Canal Sealers on Postoperative Pain and Sealer Extrusion: A Multicenter Randomized Clinical Study

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CE Hours: 1.0

Description: Postoperative pain remains a critical concern in endodontic treatment, influenced by multiple factors, including the choice of root canal sealer. Calcium silicate–based sealers like NeoSealerFlo offer biocompatibility and bioactivity, while resin-based sealers such as AH Plus are widely regarded as the gold standard in endodontics. This study aimed to compare postoperative pain and sealer extrusion between these two materials in a large-scale clinical setting.

At the conclusion of this article, the reader will be able to: 

  • Describe the differences in postoperative pain between Calcium Silicate-Based and Resin-Based root canal sealers over time.
  • Examine differences in postoperative pain related to pulpal diagnosis. 
  • Discuss the factors that may contribute to postoperative pain and pain resolution. 

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The Impact of Calcium Silicate–Based and Resin-Based Root Canal Sealers on Postoperative Pain and Sealer Extrusion: A Multicenter Randomized Clinical Study
Open to download resource.
Open to download resource. Published 11/1/2025
Evaluation
8 Questions
CE Test
5 Questions  |  Unlimited attempts  |  4/5 points to pass
5 Questions  |  Unlimited attempts  |  4/5 points to pass
Certificate
1.00 CE credit  |  Certificate available
1.00 CE credit  |  Certificate available

Pablo Ensinas, DDS, MSc

José Aranguren, D.D.S., M.S.

José Aranguren Cangas Dr. José Aranguren received his Doctor Of Dental Surgery Degree in 2000, from the Universidad Europea de Madrid(UEM), in Madrid, Spain. He has practicing exclusively Endodontics since 2000. Dr. Aranguren received his Specialty Certificated in Endodontics from the Southern Mississippi University (USM), Madrid. He has been involved in academics since 2003, and practicing exclusively Endodontics in Madrid, Spain. His major area of scientific research interest include the performance of nickel-titanium endodontic instruments, and Metalurgia. Dr. Aranguren is an internationally recognized lecturer; he is the author of numerous scientific papers published in peer-reviewed journals as well as dental magazines. And also coautor of the book “Microdentistry a practical guide”. (2014). Dr. Aranguren is Associate Professor of Endodontics at the University Rey Juan Carlos of Madrid and Professor of the Director of thr Postgraduate program in Advanced Endodontics at the Rey Juan Carlos University. Now he is also a Faculty member at the International Dental Institute (IDI) and International Endodontic Institute (IEI) in Fort Lauderdale and Palm Beach Gardens, Florida. He is the secretary of the Spanish Society of Endodontics, Member of the American Association of Endodontics and Member of the Carl Zeiss Dental Academy.

Vincenzo Tosco, DDS, PhD

Kenneth Pineda, DDS, MSc, PhD

Giulia Malvicini, DDS

Alejandro R. Perez, DDS, MSc, PhD