The Link Between Apical Periodontitis and Gastrointestinal Diseases—A Systematic Review
CE Hours: 1.0
Description: This systematic review aimed to examine a potential link between apical periodontitis (AP) and gastrointestinal diseases (GIDs).
At the conclusion of this article, the reader will be able to:
- Discuss low-grade inflammation induced by apical periodontitis
- Evaluate an appropriate structure of well-performed systematic review in Endodontics
- Analyze endodontic findings of patients with gastrointestinal diseases
Key:

Aleksandar Jakovljevic, D.D.S.

Francesca Ideo, PhD

Jelena Jacimovic, PhD
Anita Aminoshariae, DDS, MSc
Dr. Anita Aminoshariae is a professor (with tenure) and director of Predoctoral Endodontics at Case Western Reserve University. Her dental career commenced when she was accepted to the Pre-Professional Scholars Program, Six-Year Dentistry at Case School of Dental Medicine. She then worked as a contract dentist for the United States Navy. She obtained her endodontic training, certificate and masters from Virginia Commonwealth University in 2003. She became a Diplomate of the American Board of Endodontics in 2005. Dr. Aminoshariae is a member of the American Dental Association, Ohio Dental Association Ohio Association of Endodontists andthe Council of Scientific Affairs (ADA). She is a spokesperson on the topic of opioids in dentistry (ADA) and asite visitor, Commission on Dental Accreditation (CODA). She has served on the American Association of Endodontists’ Board of Directors and as president of the Greater Cleveland Dental Society. She is a member of the Scientific Advisory Boards for the Journal of Endodontics and Journal of the American Dental Association and is an associate editor for the Journal of Endodontics. Dr. Aminoshariae has published numerous articles in the field of endodontics and evidence-based dentistry.

Venkateshbabu Nagendrababu, BDS, MFDS RCS (Glasg), MDS, PhD
Venkatesh Babu N is an Associate Professor in the Department of Preventive and Restorative Dentistry, College of Dental Medicine, University of Sharjah, United Arab Emirates. He has a background in academia and research that spans over 16 years. He is currently an Associate Editor for the International Endodontic Journal, the official journal of the British Endodontic Society and the European Endodontic Society and also serves as Associate Editor for Dental Traumatology, the official journal of the International Association of Dental Traumatology. He has published 181 peer-reviewed papers and has been awarded 21 research projects totaling approximately $101,000 USD. He is a project leader for the development of reporting guidelines for various study designs in Endodontology - "Preferred Reporting Items for Endodontic Study Designs (PRIDE)".
Amir Azarpazhooh, D.D.S., M.SC., F.R.C.D. (C) (DPH), CERT. ENDO., PhD, F.R.C.D. (C) (ENDO), Dip ABE
Dr. Amir Azarpazhooh (pronounced “Azar pa joo”) earned his DDS (Iran, 2001) and completed graduate training in Dental Public Health (2007), Endodontics (2010), and a PhD (2011) at the University of Toronto. He is a tenured Full Professor of Dentistry at the University of Toronto, specializing in Dental Public Health and Endodontics, and a Professor of Clinical Epidemiology at the Dalla Lana School of Public Health. He is also an investigator with the Toronto Health Economics and Technology Assessment Collaborative and leads the Divisions of Endodontics and Research at Mount Sinai Hospital. He has secured $1.5 million in research funding, supervised forty-five MSc and PhD trainees, edited an evidence-based dentistry textbook, authored seven book chapters, and published three hundred papers. His work has been cited over seven thousand times and is reflected in an H-index of forty-four and an I10-index of ninety-nine. He has delivered more than ninety presentations at national and international meetings and has received honours from Cochrane Canada, the Canadian Academy of Endodontics, the American Association of Endodontists, the WW Wood Award for Excellence in Dental Education, and multiple Journal of Endodontics Publication Awards (2020–2024). He also serves as an Associate Editor for the Journal of Endodontics. He is a Board-Certified Diplomate and Director of the American Board of Endodontics (2025–2028), and a fellow, examiner and a member of Board of Directors of the Royal College of Dentists of Canada. He practices part-time in a multi-specialty setting in Toronto and provides endodontic care to medically compromised patients at Mount Sinai Hospital.
I declare that I have NO past or present proprietary or relevant, financial relationship or receive gifts in kind (including soft intangible remuneration), consulting position or affiliation, or other personal interest of any nature or kind in any product, service, course and/or company, or in any firm beneficially associated therewith.
Elisabetta Cotti, D.D.S., M.S.
Elisabetta Cotti, DDS, MS, received her DDS from the University of Cagliari – Italy and the specialty and MS in Endodontics from the University of Loma Linda- California.
She is Full Professor of Conservative Dentistry and Endodontics, and the Chairman of the Department of Conservative Dentistry and Endodontics at the School of Dentistry, University of Cagliari- Italy. She is currently the Director of the Post Graduate programme (Master) in Clinical Endodontics at the University of Cagliari, lecturer in the Department of Endodontics at Loma Linda University, USA. She is the president of IFEA (International federation of Endodontic Associations). She practices limited to Endodontics, and is author of several articles and chapters in the field of Endodontics with has a specific interest in apical periodontitis, imaging and trauma.
Disclosure(s): Dentsply Sirona Endodontic SBU: Honorarium (Ongoing), serve as consultant in products development and as lectures (Ongoing)