Journal of Endodontics Articles

Scientific articles, case reports, and comparison studies evaluating materials and methods of pulp conservation and endodontic treatment published in the JOE, the official journal of the AAE.

JOE Articles

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  • Product not yet rated Includes Credits

    CE Hours: 1.0

    Description: The aim of this study was to leverage label-efficient self-supervised learning (SSL) to train a model that can detect ECR and differentiate it from caries.

    At the conclusion of this article, the reader will be able to: 

    • Describe the value and importance of self-supervised learning methods in the field of artificial intelligence (AI). 
    • Describe the function of AI models in detecting external cervical resorption (ECR) and differentiating it from root/tooth caries.
    • Describe the value of introducing AI to the field of Endodontics for detecting ECR. 

    Hossein Mohammad-Rahimi, DDS

    Omid Dianat, DDS, MS, MDS

    Reza Abbasi, MSc

    Samira Zahedrozegar, DDS

    Ali Ashkan, DDS

    Saeed Reza Motamedian, DDS, MS

    Mohammad Hossein Rohban, MHR

    Ali Nosrat, DDS, MS, MDS

    Dr. Ali Nosrat is currently a part-time Clinical Assistant Professor at the School of Dentistry, University of Maryland in Baltimore. Dr. Nosrat received his specialty degree in Endodontics and Masters of Oral Biology in June 2015. He became a Diplomate of the American Board of Endodontics in June 2016. Dr. Nosrat maintains a full-time private practice limited to Endodontics in Northern Virginia.
    Dr. Nosrat holds a Doctor of Dental Surgery (DDS, 2002) and Master of Science (MS) and a specialty degree in Endodontics from Tehran Dental School, Iran (2002). He received his Board Certification from Iranian Association of Endodontist in 2007. 
    Dr. Nosrat currently serves on the Research and Scientific Affairs Committee at the AAE. He is a member of the Scientific Advisory Board for the Journal of Endodontics and a scientific reviewer for International Endodontic Journal and Dental Traumatology. He has published more than 50 articles in the fields of pain, vital pulp therapy in immature teeth, regenerative endodontics, root canal anatomy, management of resorptions, and the impacts of COVID-19 pandemic on endodontic patients.

  • Product not yet rated Includes Credits

    CE Hours: 1.0

    Description: This study assessed the accuracy of a TMD Pain Screener questionnaire in identifying patients with temporomandibular disorder (TMD) pain among those seeking endodontic treatment for tooth pain. It also investigated whether the screener accuracy could be improved by adding questions regarding putative predictors of TMD status.

    At the conclusion of this article, the reader will be able to: 

    • Utilize the brief temporomandibular disorder (TMD) pain screening tool in endodontic patients with history of tooth pain to identify those who may need a more thorough TMD examination.
    • List the components of the TMD pain screening questionnaire and describe scoring and interpretation of the screening results using a proposed interpretation grid. 
    • Discuss the diagnostic accuracy of the TMD Pain Screener alone and in combination with the endodontic patient’s rating of the current pain intensity of the chief complaint. 

    Iryna H. Daline, D.M.D., M.S.

    Dr. Iryna Daline is a board-certified Orofacial Pain specialist and a board-eligible Endodontist. She completed her orofacial pain residency at the University of Minnesota and endodontic residency at the University of North Carolina at Chapel Hill. Her clinical and research interests include differential diagnosis, comorbidity, and treatment of endodontic pain and other orofacial pain conditions. She has received grants from the American Association of Endodontists, American Board of Orofacial Pain, International Association for Dental Research, and Dental Foundation of North Carolina to support her research bridging endodontics and orofacial pain. She has published articles in the Journal of Endodontics, Journal of Oral Rehabilitation, and Cephalalgia. Dr. Daline is a co-author of chapters on non-odontogenic pain in the 3rd edition of Seltzer and Bender's Dental Pulp and the 7th edition of Principles and Practice of Endodontics. She has been repeatedly invited to speak and share her expertise with both dental and endodontic professionals.

    Speaker Disclosure 

    I declare that I have no proprietary, financial, or other personal interest of any nature or kind in any product, service, course, and/or company, or in any firm beneficially associated therewith, that will be discussed or considered during the proposed presentation.

    Gary D. Slade, BDSc, DDPH, PhD

    Dr. Slade undertook dental training at the University of Melbourne, Australia (BDSc, 1982) and completed the Diploma in Dental Public Health at the University of Toronto, Canada (DDPH, 1988). He obtained his PhD in dentistry at the University of Adelaide (1994). Dr. Slade is currently the John W. Stamm Distinguished Professor of Dentistry at the University of North Carolina at Chapel Hill. His principal research interests are in population assessment of oral health related quality of life, epidemiological studies of oral disease and orofacial pain, public health interventions to prevent oral disease, and clinical interventions to treat orofacial pain. Dr. Slade published over 288 articles and 8 book chapters. In 2004, he was awarded the distinguished scientist award for Geriatric Oral Research from the International Association for Dental Research (IADR), and in 2008 he was awarded the IADR’s H. Trendley Dean Award for research in epidemiology and public health.

    Ashraf F. Fouad, D.D.S., M.S.

    Dr. Fouad obtained his DDS, Certificate of Endodontics and MS at the University of Iowa. 

    He served on the faculty and in various administrative roles at University of Connecticut, the University of Maryland, and the University of North Carolina at Chapel Hill. He is currently Professor and Chair, Department of Endodontics, Director, Advanced Endodontics Program, and Interim Director, Health Information and Business Systems (HIBS) at the University of Alabama at Birmingham.

    Dr. Fouad has published over 110 peer-reviewed manuscripts, 25 textbook chapters, and 145 abstracts. He edited and co-authored the textbooks: Endodontic Microbiology (now in its second edition), as well as the fifth and sixth editions of Endodontics: Principles and Practice. He is a Diplomate and Past President of the American Board of Endodontics, and an Associate Editor of the Journal of Endodontics, Dental Traumatology and Frontiers of Dental Medicine – Endodontics. He received the Distinguished Scientist Award from the Pulp Biology and Regeneration Group of the International Association of Dental Research in 2017, and the AAE President’s Award in 2022.

    Speaker Disclosure

    I declare that I have no proprietary, financial, or other personal interest of any nature or kind in any product, service, course, and/or company, or in any firm beneficially associated therewith, that will be discussed or considered during the proposed presentation

    Donald R. Nixdorf, DDS, MS

    After graduating from the University of Alberta Faculty of Dentistry, Dr. Nixdorf completed hospital dentistry residency at The Ohio State University, Anesthesia fellowship at Johns Hopkins University, Orofacial Pain fellowship at the University of Alberta, and a Master of Science in Clinical Research at the University of Minnesota. As a Diplomate of the National Dental Board of Anesthesiology (NDBA) and the American Board of Orofacial Pain (ABOP), he maintains a specialty Orofacial Pain practice on the diagnoses and management of chronic TMD pain, headaches, and neuropathic pain within multi-disciplinary settings. Dr. Nixdorf’s research has focused on the topics of non-odontogenic “tooth” pain from a classification, diagnosis, epidemiology, and treatment perspectives, as well as TMD and, most recently, dental MRI, with over 85 published articles. Dr. Nixdorf is Professor, Division Director, and past Graduate Program Director at the University of Minnesota in the Division of TMD & Orofacial Pain.

    Inna E. Tchivileva, MD, MS

    Dr. Tchivileva is Assistant Professor in the Division of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill. She obtained her MD and MS in Biochemistry from the Russian State Medical University, Moscow, Russia. She then completed her post-doctoral training in pain neurobiology, molecular biology, and genetics at the Center for Pain Research and Innovation, Adams School of Dentistry, University of North Carolina at Chapel Hill. Dr. Tchivileva’s research interests comprise such topics as association between TMD and headache, molecular biomarkers for TMD and migraine, the role of genetic variations in nociception, and personalized pain management. She has been a recipient of several NIH awards including the K12 award for the Biomedical Researcher Development in TMD and Orofacial Pain and served as a co-Principal Investigator for a large multisite clinical trial in TMD. Dr. Tchivileva has published 21 peer-reviewed manuscripts, 2 textbook chapters, and 22 refereed abstracts. 

  • Includes Credits

    CE Hours: 1.0

    Description: This study aimed to assess the canal transportation with 6 preparation systems.

    At the conclusion of this article, the reader will be able to: 

    • Gain insight into variations in the definition of root canal transportation in both clinical and research perspectives.
    • Examine how different types of NiTi systems contribute to root canal transportation, understanding their distinct impacts on the process.
    • Acknowledge the influence of factors such as instrument design and metallurgy on root canal transportation.

    Felipe Gonçalves Belladonna DDS, MSc, PhD

    Adjunct Professor at Fluminense Federal University - Niterói, Rio de Janeiro, Brazil

    Tiago de Mello Guimarães DDS, MSc

    PhD student at Fluminense Federal University - Niterói, Rio de Janeiro, Brazil

    Emmanuel Jo~ao Nogueira Leal Silva, D.D.S., M.Sc., Ph.D.

    Adjunct Professor at Grande Rio University - Caxias, Rio de Janeiro, Brazil

    Adjunct Professor at Rio de Janeiro State University - Rio de Janeiro, Rio de Janeiro, Brazil

    Adjunct Professor at Fluminense Federal University - Niterói, Rio de Janeiro, Brazil

    Esio de Oliveira Vieira DDS, MSc, PhD

    Associate Professor at Fluminense Federal University - Niterói, Rio de Janeiro, Brazil

    Jong-Ki Lee DDS, MSc, PhD

    Private Practice, Changwon, Republic of Korea

    Evaldo de Almeida Rodrigues DDS, MSc, PhD

    Adjunct Professor at Feira de Santana State University - Feira de Santana, Salvador, Brazil

    Erick Miranda Souza DDS, MSc, PhD

    Associate Professor at Maranhão Federal University - São Luís, Maranhão, Brazil

    Marco Aurelio Versiani, D.D.S., M.Sc., Ph.D.

    Dr. Versiani received his degree in Dentistry in 1992. Since 1994, he has been working part-time as a dentist in the Dental Department of the Brazilian Military Police in which he held the grade of Colonel. He is a certified specialist in Endodontics (1994), Didactics (1998) and Bioethics (2003). Dr. Versiani concluded his Master Degree, PhD, and 3 postdoctoral fellowships at the University of Sao Paulo by the year of 2015. In the endodontic literature, he contributed with 3 books, 36 book chapters, and more than 130 peer-reviewed papers in high impact journals. Currently, he is a member of the scientific advisory panel of the Journal of Endodontics and the Editorial Board of the International Endodontic Journal. Dr. Versiani lectures worldwide focusing on his main research interests that are the influence of root canal anatomy on endodontic procedures using non-invasive 3D X-ray micro-computed tomography and CBCT, towards the improvement of both chemical and mechanical debridement of root canals.

  • Includes Credits

    CE Hours: 1.0

    Description: This systematic review aimed to examine a potential link between apical periodontitis (AP) and gastrointestinal diseases (GIDs).

    At the conclusion of this article, the reader will be able to: 

    • Discuss low-grade inflammation induced by apical periodontitis
    • Evaluate an appropriate structure of well-performed systematic review in Endodontics
    • Analyze endodontic findings of patients with gastrointestinal diseases

    Aleksandar Jakovljevic, D.D.S.

    Francesca Ideo, PhD

    Jelena Jacimovic, PhD

    Anita Aminoshariae, DDS, MSc

    Dr. Anita Aminoshariae is a professor (with tenure) and director of Predoctoral Endodontics at Case Western Reserve University. Her dental career commenced when she was accepted to the Pre-Professional Scholars Program, Six-Year Dentistry at Case School of Dental Medicine. She then worked as a contract dentist for the United States Navy. She obtained her endodontic training, certificate and masters from Virginia Commonwealth University in 2003. She became a Diplomate of the American Board of Endodontics in 2005. Dr. Aminoshariae is a member of the American Dental Association, Ohio Dental Association Ohio Association of Endodontists andthe Council of Scientific Affairs (ADA). She is a spokesperson on the topic of opioids in dentistry (ADA) and asite visitor, Commission on Dental Accreditation (CODA). She has served on the American Association of Endodontists’ Board of Directors and as president of the Greater Cleveland Dental Society. She is a member of the Scientific Advisory Boards for the Journal of Endodontics and Journal of the American Dental Association and is an associate editor for the Journal of Endodontics. Dr. Aminoshariae has published numerous articles in the field of endodontics and evidence-based dentistry.

    Venkateshbabu Nagendrababu, BDS, MFDS RCS (Glasg), MDS, PhD

    Amir Azarpazhooh, D.D.S., M.Sc., Ph.D.

    Dr. Amir Azarpazhooh received his DDS from Iran (2001), his speciality training at the University of Toronto (UofT) in Dental Public Health (2007) and endodontics (2010), followed by his PhD in 2011. He is a UofT full-time tenured Associate Professor, with cross-appointments to the Clinical Epidemiology Program at the Institute of Health Policy, Management and Evaluation, Faculty of Medicine, and Toronto Health Economics and Technology Assessment Collaborative, UofT. He is also the Head of both Divisions of Endodontics and Research at the Department of Dentistry, Mount Sinai Hospital, Toronto.

    Currently, his attributed grants and awards total more than CDN $1.25M and these have enabled him to manage a strong group of graduate students over the years. To date, he has been an editor of a textbook on evidence-based dentistry, has published six book chapters, and more than 150 papers, abstracts and reports and has presented at over 50 national and international scientific meetings. He has been awarded nationally and internationally, by the Cochrane Canada, the Canadian Academy of Endodontics, and the American Association of Endodontists. He is an Associate Editor of the Journal of Endodontics.

    Amir is a practicing endodontist, with part-time private practices in Toronto as well as a hospital practice in Mount Sinai Hospital providing endodontic care to patients when their medical, physical or mental status indicates the need for a hospital environment. Despite his heavy load of teaching, research and clinical practice, out of the office he enjoys life with his wife, travelling, cycling, photography, and gardening.

    Elisabetta Cotti, D.D.S., M.S.

    Elisabetta Cotti, DDS, MS, received her DDS from the University of Cagliari – Italy and the specialty and MS in Endodontics from the University of Loma Linda- California. She is Full Professor of Conservative Dentistry and Endodontics, and the Chairman of the Department of Conservative Dentistry and Endodontics at the School of Dentistry, University of Cagliari- Italy. She is currently the Director of the Post Graduate programme (Master) in Clinical Endodontics at the University of Cagliari. She teaches in the Advanced Education Programs in Endodontics at the University of Bologna and she is lecturer in the Department of Endodontics at Loma Linda University, USA. She is the Treasuree for IFEA, active member of the AAE, of the Italian Association of Endodontics (SIE), Italian Academy of Endodontics (AIE), of the European Association (ESE). She is the Past President of the Italian Society of Dental Traumatology (SIDT). She practices limited to Endodontics, She is author of several articles and chapters in the field of Endodontics with has a specific interest in apical periodontit

  • Product not yet rated Includes Credits

    CE Hours: 1.0

    Description: This epidemiological analysis used procedure codes from dental insurance claims data to identify apexification cases and evaluate survival at the toothlevel.

    At the conclusion of this article, the reader will be able to: 

    • Describe the survival of apexification procedures, with an average follow-up time of 64 months, performed in a United States population.
    • Compare survival rates of apexification reported in this study to success rates of apexification previously reported in the endodontic literature.
    • Describe potential barriers to access to care for treatment for immature permanent teeth, as discussed in this manuscript.

    Lorel E. Burns, D.D.S.

    Dr. Lorel Burns is a clinician-investigator and assistant professor at New York University (NYU) College of Dentistry. She is a Diplomate of the American Board of Endodontics. Dr. Burns earned her DDS degree at NYU College of Dentistry, completed her specialty training in Endodontics at the University of Pennsylvania School of Dental Medicine and was awarded her master’s degree in Clinical Investigation by NYU School of Medicine. In 2019, she was selected as the American Association of Endodontists (AAE) Foundation’s Endodontic Educator Fellow. In 2022, she recognized with the American Dental Education Association (ADEA) Junior Faculty Award. Dr. Burns’ research interests include endodontic treatment outcomes, access to dental care, clinician decision-making, and dental education. Her research has been funded by the National
    Institutes of Health (NIH)/ National Institute of Dental and Craniofacial Research (NIDCR), the Robert Wood Johnson Foundation (RWJF), and the American Dental Education Association, ADEAGies Foundation. Her work has been published in peer- reviewed journals including the Journal of Endodontics (JOE), the International Endodontic Journal (IEJ), the Journal of the American Dental Association (JADA), and the Journal of Dental Education (JDE). Dr. Burns maintains part-time private practice limited to Endodontics in New York, USA.

    Speaker Disclosure:

    I declare that I have no proprietary, financial, or other personal interest of any nature or kind in any product, service, course, and/or company, or in any firm beneficially associated therewith, that will be discussed or considered during the proposed presentation.

    Nihan Gencerliler, MPH

    Nihan Gencerliler has a master’s degree in public health, with an advanced certificate in applied biostatistics. She participated in this study as an Assistant Research Scientist in the Department of Endodontics and New York University College if Dentistry.

    Kelly Terlizzi, MS

    Kelly Terlizzi has a master’s degree in clinical research. She participated in this study as an Analyst at New York University Health Evaluation and Analytics Lab.

    Claudia Solis-Roman, MSc, MPA

    Claudia Solis-Roman has master’s degrees in public administration and applied statistics. She participated in this study as a Lead Analyst at New York University Health Evaluation and Analytics Lab.

    Asgeir Sigurdsson, D.D.S., M.S.

    DDS from University of Iceland. Graduated from University of North Carolina (UNC) in 1992, with certificate in endodontics and MS. Full time faculty at UNC 1992-2004, was the Graduate Program Director of Endodontics 1997 to 2004. From 2004 to 2012 in a private endodontic practice in Reykjavik, Iceland and London, UK and Honorary Clinical Teacher in Endodontology, UCL Eastman Dental Institute, UK. In 2012, he became the Chairman and tenured Professor at NYU Dentistry, Department of Endodontics. Additionally, he is an adjunct Professor at UNC. Dr. Sigurdsson is past President of the International Association for Dental Traumatology and 2014 he was appointed as a Director of the American Board of Endodontics and served as the President of the Board 2019-20. He is currently on the editorial board of Dental Traumatology. Dr. Sigurdsson has been invited numerous times to lecture in 47 countries all over the world, on the topics of pain, endodontics, dental trauma and/or forensic sciences. He has written or co-written over 85 per-reviewed articles and 23 textbook chapters on same topics. 

    Speaker Disclosure:

    I declare that I have no proprietary, financial, or other personal interest of any nature or kind in any product, service, course, and/or company, or in any firm beneficially associated therewith, that will be discussed or considered during the proposed presentation.

    Heather T. Gold, PhD

    Dr. Heather T. Gold is a Professor in the Department of Population Health and NYU Langone Health. She has a health economist and health services researcher.

  • Includes Credits

    CE Hours: 1.0

    Description: This study evaluated the effects of diabetes mellitus (DM) on the nanostructure of root canal dentin using high-resolution transmission electron microscopy (HRTEM) and inductively coupled plasma mass spectrometry (ICP-MS).

    At the conclusion of this article, the reader will be able to: 

    • Evaluate the impact of diabetes mellitus on the elemental composition of dentin, with a focus on copper (Cu), lithium (Li), zinc (Zn), selenium (Se), strontium (Sr), manganese (Mn), and magnesium (Mg)
    • Describe the nanostructural differences in dentin between diabetic and non-diabetic patients, as observed through high-resolution transmission electron microscopy (HRTEM)
    • Discuss the potential consequences of altered dentin composition and nanostructure in diabetic patients for root canal treatment outcomes

    Mohammad Ali Saghiri, DEng, MS, PhD

    MA Saghiri holds PhD degrees in biomedical engineering and medical laboratories, specializing in dental materials and medical devices. During his tenure as a visiting scholar at the University of Michigan School of Dentistry, he collaborated under the guidance of the late Prof. Kamal Asgar, contributing to over 20 published articles. Dr. Saghiri commenced his academic career as an Assistant Professor of Dental Materials at Azad Dental School in 2012, eventually advancing to the position of Associate Professor and IT head. Returning to the US in 2013, he joined Prof. Nader Sheibani’s Lab as an Assistant Scientist in the Department of Ophthalmology and Visual Sciences. Following the completion of postdoctoral studies, he transitioned to Philips Inc. as a Clinical and Biological Scientist, focusing on cutting-edge technology for oral hygiene care until 2018. Currently, Dr. Saghiri serves as the Director of the Biomaterials Research Center and an Assistant Professor in the Department of Restorative Dentistry at Rutgers School of Dental Medicine. Additionally, he holds the position of Adjunct Assistant Professor in the Department of Endodontics at the University of the Pacific School of Dentistry. With a prolific publication record, Dr. Saghiri has authored and co-authored over 130 articles in peer-reviewed dental journals spanning scientific, research, educational, and clinical themes. Recognized for his exceptional contributions, he received three awards at Azad Dental School and is the recipient of the NSF-DMR-2312680, NSF-STTR- 2321456 Awards, along with several other accolades such as TechAdvance and NJ ACT. Notably, he was honored with the DenburTech Award, a distinction reserved for clinical scientists under 40 who have published over 100 articles in the field.

    Julia Vakhnovetsky, BS

    Julia Vakhnovetsky has a BS degree from Rutgers University with a major in Biological Sciences. She is currently a dental student at the University of Michigan School of Dentistry. She has authored and co-authored over 15 articles in peer-reviewed dental journals that address scientific, research, educational, and clinical topics in endodontics, oral hygiene, dentinal health, diabetes, and artificial intelligence. 

    Elham Samadi, DDS

    Elham Samadi is an international dentist who recently joined the Biomaterials Research Lab at Rutgers School of Dental Medicine. Her focus is on the impact of various systemic diseases on the quality of dentin and the longevity of dental treatments, with a particular interest in diabetes mellitus.

    Salvatore Napoli, DDS, MD, FACS

    Salvatore Napoli received his DDS degree from Columbia University School of Dental and Oral Surgery in 1979. He then pursued residency programs in dental anesthesiology and oral and maxillofacial surgery from 1980 to 1986. Presently, Dr. Napoli is board certified in oral & maxillofacial surgery (OMFS), a licensed physician (MD), Fellow of the American College of Surgeons and Associate Professor at Rutgers University School of Dental Medicine. He serves as Director of Predoctoral Education in Oral & Maxillofacial Surgery as well as in OMFS Clinic I, OMFS Clinic II, Complicated Exodontia and Advanced Techniques of Pain Control.  Additionally, he is an Associate lecturer in topics such as management of patients with cardiovascular disease, allergic reactions, medical and respiratory emergencies, endocrine disorders, and oral pathology.

    Fatereh Samadi, DDS

    Fatereh Samadi, an accomplished international dentist, has recently become a member of the Biomaterials Research Lab at Rutgers School of Dental Medicine. With over a decade of experience in private practice, specializing in orthodontics, she brings a wealth of knowledge to her current role. Her expertise extends to the evaluation of innovative polyurethane-based sealers in the realm of orthodontic and endodontic biomaterials. During her extensive tenure in private practice, She has authored more than eight articles. Her dedication and contributions have not gone unnoticed, as evidenced by the multiple awards she has received for her outstanding work in private practice.

    Michael Conte, DMD, MPH

    Michael Conte received his DMD from Rutgers School of Dental Medicine and completed his MPH at Rutgers. He is the Senior Associate Dean for the office of Clinical Affairs and is a Full Professor in the Department of Restorative Dentistry. Dr Conte serves as Medical Director of Rutgers School of Dental Medicine as well as the Director of Infection Control and Environmental Safety. Dr. Conte also oversees the dental school's Office of Facilities and the school Extramural Programs.  Dr. Conte is a highly respected dentist and educator.

    Steven M. Morgano, DMD

    Steven M. Morgano is a fellow of the American College of Prosthodontists, a past president of the Massachusetts section, and has been a member of the College since 1979. He has taught at eight different dental schools, including Boston University and Harvard School of Dental Medicine, and at universities in Kuwait and Dubai. He is currently a professor and chairman of the Department of Restorative Dentistry at Rutgers School of Dental Medicine. Dr. Morgano received his DMD degree from Tufts University School of Dental Medicine, completed his General Practice Residency at Philadelphia General Hospital, and received his specialty certificate in prosthodontics from the Hines Veterans Affairs Medical Center in 1979. Dr. Morgano is also a Diplomate of the American Board of Prosthodontics and has authored and co-authored over 90 articles in numerous dental journals.

  • Product not yet rated Includes Credits

    CE Hours: 1.0

    Description: Increased levels of proinflammatory markers have been reported in tissues of individuals with Coronavirus Disease 2019 (COVID-19). We hypothesize that inflamed dental pulp tissues of individuals with previous history of COVID-19 may present a differential inflammatory gene expression profile in comparison with individuals who never had COVID-19.

    At the conclusion of this article, the reader will be able to: 

    • Explain molecular markers of inflamed dental pulp tissue in patients with and without history of COVID-19
    • Identify novel biological pathways involved in dental pulp inflammation
    • Describe how past COVID-19 disease status may impact dental pulp inflammation

    Han Na Cho, DMD, MSD

    Dr. Han Na Cho graduated from Mount Holyoke College in Massachusetts with a Bachelor of Arts in Biology and a minor in Chemistry. She then earned her Doctor of Dental Medicine degree at the University of Pennsylvania School of Dental Medicine in Philadelphia. After graduating from dental school, she completed a General Practice Residency (GPR) at Flushing Hospital Medical Center in New York and continued her education at the University of Texas Health Science Center at Houston, where she earned her specialty certificate in Endodontics and a Master of Science in Dentistry degree. Dr. Cho is an American Board of Endodontics eligible endodontist and is currently an active member of the American Association of Endodontists, American Dental Association, Texas Dental Association and Greater Houston Dental Society. She is currently working as an associate in a private practice in Houston. 

    Leticia Chaves de Souza, DDS, MS, PhD

    Cleverick Johnson, DDS, MS

    John R. Klein, PhD

    Timothy C. Kirkpatrick, DDS

    Dr. Timothy Kirkpatrick is a professor in the Department of Endodontics at UTHealth School of Dentistry at Houston, where he also serves as the Department Chair and Program Director of the Advanced Education in Endodontics Program.

    Renato M. Silva, D.D.S., M.S., P.h.D.

    Dr. Silva received his DDS from the University Gama Filho, Rio de Janeiro, Brazil, in 1994. He received his endodontic certificate from both Brazil (University Gama Filho) and US (University of Texas Health Science Center at Houston). Dr. Silva received his MS (2002) in Endodontics and PhD (2006) degree in Oral Sciences from University of Sao Paulo, Brazil. He also completed a postdoctoral fellowship in Human Molecular Genetics at the University of Pittsburgh. Dr. Silva worked as an Assistant Professor at University of Pittsburgh from 2007 to 2011, and Associate/Professor/Department Chair at University of Texas at Houston from 2011 to 2021. Dr. Silva is currently a Professor and Chair of the Department of Endodontics at The University of Pittsburgh, School of Dental Medicine. Dr. Silva has edited a textbook about Endodontic retreatment and published several peer-reviewed articles in the field of Endodontics and Human Genetics. He is a board-certified endodontist and maintains a faculty practice limited to Endodontics.

    Speaker Disclosure 

    I declare that I have no proprietary, financial, or other personal interest of any nature or kind in any product, service, course, and/or company, or in any firm beneficially associated therewith, that will be discussed or considered during the proposed presentation.

    Ariadne Letra, D.D.S., M.S., P.h.D.

    Dr. Ariadne Letra is a tenured professor of Oral and Craniofacial Sciences and Endodontics, and a member of the Center for Craniofacial and Dental Genetics at the University of Pittsburgh School of Dental Medicine.  

    Dr. Letra’s research focuses on gene discovery and functional genomic characterization approaches to understand the etiology of complex craniofacial and oral traits and conditions such as cleft lip/palate, tooth agenesis, and apical periodontitis. Another aspect of Dr. Letra’s work focuses on identifying host factors contributing to the interconnectedness between oral and systemic health and disease. 

    Dr. Letra has been the principal investigator for several NIH and AAE foundation grants and has served in various NIH study sections. Her residents have also been recipients of numerous AAE Resident Research grant awards and placed among the top ten winners of the AAE/Dentsply Resident Research Presentation Awards for the last ten years.

    Dr. Letra’s work has been recognized through prestigious awards including the 2020 Journal of Endodontics Best Paper in Clinical Research Award. Her work was also featured on the cover of the Journal of Endodontics, Journal of Dental Research, and Orthodontics and Craniofacial Research Journal.  Dr. Letra is a recipient of the distinguished 2018 AADR/SCADA Burton C. Borgelt Faculty 160 peer-reviewed articles, 5 book chapters, and numerous abstracts and publications in the media. She is an associate editor of the Journal of Endodontics, and a member of the editorial board of numerous medical and dental journals including the Journal of Dental Research, Journal of Dental Research Clinical and Translational Research, American Journal of Human Genetics, among others.

    Dr. Letra is currently Chair of the AAE Research and Scientific Affairs Committee.

    Disclosure

    I declare that I have no proprietary, financial, or other personal interest of any nature or kind in any product, service, course, and/or company, or in any firm beneficially associated therewith, that will be discussed or considered during the proposed presentation.

  • Includes Credits

    CE Hours: 1.0

    Description: Vital pulp therapy is increasingly practiced as an alternative treatment to root canal therapy (RCT) in teeth with carious pulp exposure. The aim of this study was to compare the outcome, quality of life (QOL), and patients’ satisfaction after full pulpotomy and RCT in mature teeth with irreversible pulpitis.

    At the conclusion of this article, the reader will be able to: 

    • Discuss the biological bases for performing full pulpotomy in teeth with symptoms of irreversible pulpitis.
    • Describe the procedure of full pulpotomy in teeth with irreversible pulpitis
    • List the outcome measures and the reported success rates for full pulpotomy compared to RCT.

    Nessrin Taha, BDS, DClinDent, PhD

    Dr Taha attained her Graduate Diploma, Clinical Doctorate in Endodontics and PhD from the University of Melbourne, Melbourne, Australia. She is a Member of the Royal College of Ireland and a fellow of the Royal Australian College of Dental Surgeons in both general dentistry and the special field of Endodontics, and a registered endodontist in Jordan and Australia.

    She is former vice dean, director of the dental teaching clinics, director of the postgraduate clinics, and head of department of conservative dentistry at Jordan University of Science and Technology, Irbid, Jordan. She is also member and former chair of the scientific committee of the Jordanian Board of Endodontics. 

    Currently she is a professor in endodontics and coordinator of the postgraduate endodontic program at Jordan university of science and technology. Research interests include; calcium silicate-based materials, regenerative endodontics and vital pulp therapy. She lectured internationally on the topic with several published laboratory based and clinical research papers. She serves in the editorial board and reviewers’ panel of more than 10 international indexed journals. 

    Speaker Disclosure 

    I declare that I have no proprietary, financial, or other personal interest of any nature or kind in any product, service, course, and/or company, or in any firm beneficially associated therewith, that will be discussed or considered during the proposed presentation.

    Alaa M. Abuzaid, MClinDent

    Yousef S. Khader, PhD

  • Includes Credits

    CE Hours: 1.0

    Description: This study investigated the effect of shaping parameters of 2 different configurations of middle mesial canals (MMCs) on the biomechanical behavior and life span of a mandibular first molar using finite element analysis (FEA).

    At the conclusion of this article, the reader will be able to: 

    • Describe the impact of both access cavity design and extent of root canal enlargement on the life span of endodontically treated mandibular molars.
    • Perform optimal shaping of middle mesial canals in mandibular molars while fulfilling the mechanical and biological objectives of cleaning and shaping.
    • List the risk factors associated with the failure of endodontically treated teeth, especially in both of mechanical and biological aspects.

    Nawar Naguib Nawar, BDS, MSc, PhD

    Nawar Naguib Nawar is a lecturer (assistant professor) of Endodontics. He got his Bachelor degree in Dentistry from the prestigious Ain Shams University in 2008. In 2014 and 2018 Nawar got his Master’s degree and PhD respectively, both from the department of Endodontics of Ain Shams University. He is an experienced endodontist with more than a decade of endodontics-limited practice. 

    Nawar joined academia in 2011 when he became a demonstrator then an assistant lecturer in the department of Endodontics in Nahda University in Baniswef (NUB). In 2014, he joined the academic staff of the British University in Egypt participating in different aspects of teaching and supervision. After being granted his PhD, he became a lecturer of Endodontics in January 2019 and since then he coauthored many publications in the Journal of Endodontics, International Endodontic journal, European Endodontic Journal, Clinical Oral Investigations as well as BMC Oral Health. He has also extended his contribution in the scientific community by reviewing for the European Endodontic Journal. 

    Nawar contributes in different aspects of both undergraduate and postgraduate programs of the British University in Egypt including lecturing, hands-on supervision, examinations, clinical work, multiple theses supervision as well as some administrative work being the one responsible for quality assurance of the endodontic undergraduate program. Nawar is the 2022 winner of the Young Investigator Research Award “YIRG” and his publications earned him the International Conference Grant – BUE “ICG” and Scopus Researcher Award – BUE “SRA” twice. 

    Mostafa M. A. Elkholy, BDS, MSc, PhD

    Dr. Mostafa Elkholy graduated from the Faculty of Oral and Dental Medicine at Cairo University in 2006. He received his endodontic training as a resident in the Endodontics Department from 2007-2008 and then as a master’s degree student in the same department where he graduated in 2012. He joined the doctoral program at Ain Shams University in 2014, where he achieved his PhD. in 2018.

    Dr. Elkholy has been serving as an Academic Instructor in the Endodontics Department for undergraduate and postgraduate programs at The British University in Egypt since 2012. He became a Lecturer of Endodontics at the same University in 2018. Dr. Elkholy is currently a senior lecturer of endodontics and the acting disciple lead in endodontics at the school of dentistry, University of Western Australia. Mostafa’s private practice has been limited to endodontics since 2008. From 2012, Dr. Elkholy has been lecturing at national and international conferences in the field of Endodontics and providing training sessions and continuing education courses covering all the scope of endo-discipline.

    Dr. Mostafa Elkholy has several international publications concerning Endodontics. Mostafa has an interest in canal instrumentation and the effect of instrumentation on root canals. He recently published a couple of articles supporting this topic in the Journal of Endodontics. In addition, Dr. Elkholy is a reviewer for the Journal of Endodontics and a member of the Editorial Board of the European Journal of Endodontics

    William Nguyen Ha, BDSc, PhD

    Associate Professor William Ha is the Head of Endodontics at the University of Sydney and Sydney Dental Hospital. He completed his Bachelor of Dental Science in 2007, Graduate Certificate in Research Commercialisation in 2012 and Doctor of Philosophy in Endodontics in 2017. He then completed his Doctor of Clinical Dentistry in Endodontics in 2021 from the University of Adelaide. He has over 30 published peer-reviewed articles, including 6 in the Journal of Endodontics. He also developed two endodontic cell phone applications, Endoprep and AAE Endocase.

    Shehabeldin Mohamed Saber, BDS, MSc, PhD

    Graduated from the Faculty of Oral and Dental Medicine, Cairo University in 1994. Then obtained the Master degree and Ph.D. Degree in Conservative Dentistry (Endodontics) from the Faculty of Dentistry, Ain Shams University, Cairo in 2000 and 2006. 

    Working currently as a professor at the Endodontic department at the British University in Egypt. Director of the Endodontics Master program, the continuing education programs and the Center of Innovative Dental Sciences (CIDS) at the British University in Egypt.

    A Key opinion leader for VDW, Septodont and Woodpecker, an active Board member of the Egyptian Association of Endodontists. An Editorial board member for the Australian Endodontic Journal, Endodontic Practice Today, BMC Oral Health, The Egyptian Dental Journal and Panendo Journal. 

    Research interests include tooth morphology and CBCT, Stem cells, tissue engineering and regenerative endodontics, endodontic biofilms, pain control, Bioceramics, instruments and instrumentation. 

    Published more than 40 international publications since 2009 in peer reviewed indexed journals
     
    Lectured internationally at conferences organized by the European society of Endodontology the Arab society of Endodontology, and the Egyptian Association of Endodontists.

    Hyeon-Cheol Kim, D.D.S., M.S.D., Ph.D.

  • Includes Credits

    CE Hours: 1.0

    Description: MicroRNAs have been shown to play a role in the pathogenesis of apical periodontitis. Upregulation of miR-10a-5p and downregulation of miR-891a-5p were previously reported in apical periodontitis samples. This study aims to perform a functional characterization of miR-10a-5p, investigating its capacity to regulate the expression of inflammatory cytokines and growth factors, as well as a possible co-regulation mechanism with miR-891a-5p in the development of apical periodontitis.

    At the conclusion of this article, the reader will be able to: 

    • List a few microRNAs that are associated with apical periodontitis.
    • Identify key cytokines and growth factors in apical periodontitis that are regulated by microRNAs.
    • Describe how microRNAs regulate apical periodontitis in a synergistic fashion.

    Zhen Shen, D.M.D., M.s.D., P.h.D.

    Dr. Zhen Shen received his PhD degree in Cell and Developmental Biology from the University of Illinois, Urbana-Champaign (2012), and the DMD degree (Magna Cum Laude) from Harvard School of Dental Medicine (2019). He received his certificate and MSD degree in Endodontics from the University of Texas Health Science Center at Houston School of Dentistry (2021) and became a diplomate of the American Board of Endodontics in 2022. Dr. Shen is currently a clinical assistant professor at the University of Texas Health Science Center at Houston School of Dentistry and also works in private practice. Dr. Shen has published several peer-reviewed articles in the field of Endodontics and Cell Biology.

    Ariadne Letra, D.D.S., M.S., P.h.D.

    Dr. Ariadne Letra is a tenured professor of Oral and Craniofacial Sciences and Endodontics, and a member of the Center for Craniofacial and Dental Genetics at the University of Pittsburgh School of Dental Medicine.  

    Dr. Letra’s research focuses on gene discovery and functional genomic characterization approaches to understand the etiology of complex craniofacial and oral traits and conditions such as cleft lip/palate, tooth agenesis, and apical periodontitis. Another aspect of Dr. Letra’s work focuses on identifying host factors contributing to the interconnectedness between oral and systemic health and disease. 

    Dr. Letra has been the principal investigator for several NIH and AAE foundation grants and has served in various NIH study sections. Her residents have also been recipients of numerous AAE Resident Research grant awards and placed among the top ten winners of the AAE/Dentsply Resident Research Presentation Awards for the last ten years.

    Dr. Letra’s work has been recognized through prestigious awards including the 2020 Journal of Endodontics Best Paper in Clinical Research Award. Her work was also featured on the cover of the Journal of Endodontics, Journal of Dental Research, and Orthodontics and Craniofacial Research Journal.  Dr. Letra is a recipient of the distinguished 2018 AADR/SCADA Burton C. Borgelt Faculty 160 peer-reviewed articles, 5 book chapters, and numerous abstracts and publications in the media. She is an associate editor of the Journal of Endodontics, and a member of the editorial board of numerous medical and dental journals including the Journal of Dental Research, Journal of Dental Research Clinical and Translational Research, American Journal of Human Genetics, among others.

    Dr. Letra is currently Chair of the AAE Research and Scientific Affairs Committee.

    Disclosure

    I declare that I have no proprietary, financial, or other personal interest of any nature or kind in any product, service, course, and/or company, or in any firm beneficially associated therewith, that will be discussed or considered during the proposed presentation.

    Renato M. Silva, D.D.S., M.S., P.h.D.

    Dr. Silva received his DDS from the University Gama Filho, Rio de Janeiro, Brazil, in 1994. He received his endodontic certificate from both Brazil (University Gama Filho) and US (University of Texas Health Science Center at Houston). Dr. Silva received his MS (2002) in Endodontics and PhD (2006) degree in Oral Sciences from University of Sao Paulo, Brazil. He also completed a postdoctoral fellowship in Human Molecular Genetics at the University of Pittsburgh. Dr. Silva worked as an Assistant Professor at University of Pittsburgh from 2007 to 2011, and Associate/Professor/Department Chair at University of Texas at Houston from 2011 to 2021. Dr. Silva is currently a Professor and Chair of the Department of Endodontics at The University of Pittsburgh, School of Dental Medicine. Dr. Silva has edited a textbook about Endodontic retreatment and published several peer-reviewed articles in the field of Endodontics and Human Genetics. He is a board-certified endodontist and maintains a faculty practice limited to Endodontics.

    Speaker Disclosure 

    I declare that I have no proprietary, financial, or other personal interest of any nature or kind in any product, service, course, and/or company, or in any firm beneficially associated therewith, that will be discussed or considered during the proposed presentation.